More infants build an oral tolerance to cow's milk protein than with any other formulas
  • Formula selection for management of children with cow milk allergy [CMA] influences the rate of acquisition of tolerance: a prospective multicenter study.

    Berni Canani R, Nocerino R, Terrin G, et al. J Pediatr. 2013 Apr 10. pii: S0022-3476(13)00284-9. doi: 10.1016/j.jpeds.2013.03.008.

    Study objective

    To prospectively evaluate the effect of various dietary choices on building tolerance in children with CMA.

    Study design

    This independent study included a total of 260 infants aged 1 month to 12 months who had been referred for a diagnostic oral food challenge and who tested positive for CMA. Infants were divided into 5 groups based on the formula they were fed at study entry. After 12 months, investigators performed a full clinical evaluation, skin prick test, atopy patch test, and a double-blind, placebo-controlled food challenge (DBPCFC) to determine whether the children had built a tolerance to cow’s milk. If children had a negative DBPCFC after 12 months, they were reassessed 6 months later.


    Significantly more infants built oral tolerance to cow’s milk protein after 1 year of Nutramigen LGG (P<0.05)


    The current study shows that extensively hydrolyzed casein formula with LGG helps build tolerance in more infants when compared with other possible dietary regimens for the management of CMA.

    LGG = Lactobacillus GG

    Recommend Nutramigen® LGG® as your first choice for infants with CMA

    Demonstrated to work fast and help build oral tolerance

    • Manages CMA fast, sometimes within 48 hours2
    • Helps infants build a tolerance to cow’s milk fast1

    With Nutramigen LGG, families can spend less time worrying about CMA and more time enjoying the important things in life

    Building tolerance is the ultimate goal of allergy management6

    • Avoids unnecessary health care resources and costs
    • Offers a faster transition to routine cow’s milk–based products to help improve quality of life

    Works fast on CMA and helps build oral tolerance to cow’s milk protein

  • Nutramigen® with Enflora™ LGG® - For cow's milk allergy.

    LGG is a registered trademark of Valio Ltd. Nutribén hydrolyzed, Risolac, Isomil, Sinelac, Nutrilon Soya, Neocate, and Sineall are registered trademarks of entities unrelated to Mead Johnson & Company, LLC.

    References: 1. Berni Canani R et al. J Pediatr. 2013 Apr 10. pii: S0022-3476(13)00284-9. doi: 10.1016/j.jpeds.2013.03.008. [Epub ahead of print.] 2. Lothe L et al. Pediatrics. 1989;83:262-266. 3. Wood RA. Pediatrics. 2003;111:1631-1637. 4. Høst A et al. Allergy. 1990;45:587-596. 5. Bishop JM et al. J Pediatr. 1990;116:862-867. 6. Koletzko S et al. J Pediatr Gastroenterol Nutr. 2012;55:221-229.

    For more information about infant feeding and the Enfamil Family of Formulas™, call 1-800-BABY123

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