Formula selection for management of children with cow milk allergy [CMA] influences the rate of acquisition of tolerance: a prospective multicenter study.
Berni Canani R, Nocerino R, Terrin G, et al. J Pediatr. 2013 Apr 10. pii: S0022-3476(13)00284-9. doi: 10.1016/j.jpeds.2013.03.008.
To prospectively evaluate the effect of various dietary choices on building tolerance in children with CMA.
This independent study included a total of 260 infants aged 1 month to 12 months who had been referred for a diagnostic oral food challenge and who tested positive for CMA. Infants were divided into 5 groups based on the formula they were fed at study entry. After 12 months, investigators performed a full clinical evaluation, skin prick test, atopy patch test, and a double-blind, placebo-controlled food challenge (DBPCFC) to determine whether the children had built a tolerance to cow’s milk. If children had a negative DBPCFC after 12 months, they were reassessed 6 months later.
The current study shows that extensively hydrolyzed casein formula with LGG helps build tolerance in more infants when compared with other possible dietary regimens for the management of CMA.
LGG = Lactobacillus GG
Demonstrated to work fast and help build oral tolerance
Building tolerance is the ultimate goal of allergy management6
LGG is a registered trademark of Valio Ltd. Nutribén hydrolyzed, Risolac, Isomil, Sinelac, Nutrilon Soya, Neocate, and Sineall are registered trademarks of entities unrelated to Mead Johnson & Company, LLC.
References: 1. Berni Canani R et al. J Pediatr. 2013 Apr 10. pii: S0022-3476(13)00284-9. doi: 10.1016/j.jpeds.2013.03.008. [Epub ahead of print.] 2. Lothe L et al. Pediatrics. 1989;83:262-266. 3. Wood RA. Pediatrics. 2003;111:1631-1637. 4. Høst A et al. Allergy. 1990;45:587-596. 5. Bishop JM et al. J Pediatr. 1990;116:862-867. 6. Koletzko S et al. J Pediatr Gastroenterol Nutr. 2012;55:221-229.
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