Enfamil PREMIUM® Newborn

20 Cal/fl oz milk-based, iron-fortified formula for full-term newborns through 3 months

Last Updated: Wednesday, October 25, 2017 - 20:00

Description/Indication

Enfamil PREMIUM Newborn is a 20 Cal/fl oz milk-based, iron-fortified routine formula for full-term newborns through 3 months. Enfamil PREMIUM Newborn has DHA in amounts clinically demonstrated to foster cognitive development through 5 years of age1,*. Enfamil PREMIUM Newborn is patterned after early breast milk2,† with an 80:20 whey-to-casein ratio and is designed for newborns. Enfamil PREMIUM Newborn meets American Academy of Pediatrics (AAP) recommendations for vitamin D intake by providing 400 IU of vitamin D in just 27 fl oz—the approximate daily intake of a newborn. Enfamil PREMIUM Newborn offers outcomes in 3 key areas: brain development, immune health and growth.

Product Features:

  • DHA at the clinically proven* amount of 0.32% of total fatty acids, the same amount as the worldwide breast milk average3,‡, and double the amount found in the leading competitor’s product§:
    • Clinically proven* to support mental, visual and immune system development
    • Clinically shown to improve long-term cognitive outcomes through 5 years of age1,*
    • Shown to improve respiratory health through the first 3 years of life when infants were fed through 12 months4,*
  • A Natural Defense® Dual Prebiotic blend of GOS (galactooligosaccharides) and PDX (polydextrose) at 4 g/L is clinically proven to:
    • Support immune health by promoting the growth of beneficial bacteria (bifidobacteria and lactobacilli)5,6
    • Promote soft stools similar to those reported for breastfed infants7
  • Proprietary Triple Health Guard® blend of brain-nourishing DHA, an exclusive dual prebiotic blend and 30 total nutrients for growth
  • Easy-to-digest, 80:20 whey-to-casein protein blend patterned after early breast milk2,†
  • Provides 400 IU of vitamin D in just 27 fl oz
  • Inositol at the average amount found in breast milk||
  • Non-GMO
  • Kosher

* Studies compared infants fed Enfamil®with DHA and ARA vs. discontinued Enfamil without DHA and ARA; studied before the addition of prebiotics.
† Based on whey-to-casein ratio 3-5 days after lactation begins.
‡ Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women3.
§ Enfamil PREMIUM Newborn has not been shown superior to the leading competitor in promoting brain and eye development. The level of DHA in Similac Pro-Advance is ~0.15% of total fatty acids.
|| The global average total inositol level in mature breast milk over the course of lactation is 22 mg/100 kcal8.
¶ Ingredients not genetically engineered. Trace amounts of genetically engineered material may be present in the product, such as from manufacturing environments and process sources. For more information, visit enfamil.com/nonGMO.

  • Nutrients
    • (Normal Dilution)

      Per 100 Calories (5 fl oz)

      Per 100 mL

      Per 100 grams Pwder (510 Cal)

      Protein, g

      2.1

      1.42

      10.7

      Fat, g

      5.3

      3.6

      27

      Linoleic acid, mg

      780

      530

      4000

      Carbohydrate, g

      11.2

      7.6

      57

      Water, g

      133

      90

      2

      Vitamins/Other Nutrients

      Vitamin A, IU

      300

      200

      1530

      Vitamin D, IU

      75

      51

      380

      Vitamin E, IU

      2

      1.35

      10.2

      Vitamin K, mcg

      9

      6.1

      46

      Thiamin (Vitamin B1), mcg

      80

      54

      410

      Riboflavin (Vitamin B2), mcg

      140

      95

      710

      Vitamin B6, mcg

      60

      41

      310

      Vitamin B12, mcg

      0.3

      0.2

      1.53

      Niacin, mcg

      1000

      680

      5100

      Folic acid (Folacin), mcg

      16

      10.8

      82

      Pantothenic acid, mcg

      500

      340

      2600

      Biotin, mcg

      3

      2

      15.3

      Vitamin C (Ascorbic acid), mg

      12

      8.1

      61

      Choline, mg

      24

      16.2

      122

      Inositol, mg

      24

      16.2

      122

      Minerals

      Calcium, mg

      78

      53

      400

      Phosphorus, mg

      43

      29

      220

      Magnesium, mg

      8

      5.4

      41

      Iron, mg

      1.8

      1.22

      9.2

      Zinc, mg

      1

      0.68

      5.1

      Manganese, mcg

      15

      10.1

      77

      Copper, mcg

      75

      51

      380

      Iodine, mcg

      15

      10.1

      77

      Selenium, mcg

      2.8

      1.89

      14.3

      Sodium, mg

      27

      18.3

      138

      Potassium, mg

      108

      73

      550

      Chloride, mg

      63

      43

      320

      Product nutrient values and ingredients are subject to change. Please see product label for current information.

  • Nutrient Facts
    • Nutrient Density

      20 Calories/fl oz

      Protein (% Calories)

      8.5

      Whey:Casein Ratio

      80:20

      Fat (% Calories)

      48

      Carbohydrate (% Calories)

      43.5

      Potential Renal Solute Load (mOsm/100 Calories)9

      19.1

      Potential Renal Solute Load (mOsm/100 mL)9

      12.9

      Osmolality (mOsm/kg water)

      300

      Osmolarity (mOsm/L)

      270

      Lactose-free

      No

  • Product Forms

      Enfamil PREMIUM® Newborn is available in powder and ready-to-use liquid.

      When using this information, please note the following:

      Coding systems and reimbursement allowable rates vary by payer:

      • Medicare Part B uses HCPCS (Healthcare Common Procedure Coding System) to group products
      • Medicaid systems vary by state; some use HCPCS while others use NDC format code or systems of their own—contact your state provider for more information
      • Private health insurance and managed care companies may use HCPCS, NDC format code or their own system—contact your provider for more information

    • Product: Enfamil PREMIUM® Newborn
      Item #: 165701
      Description: RTU, 20 Cal
      Unit Size: 2 fl oz bottle
      Calories/Unit: 40
      Product Yield/Unit (fl oz): 2
      Case: 48 bottles per case
      HCPCS Code: B4158
      NDC Format Code: 00087-1657-41
    • Product: Enfamil PREMIUM Newborn
      Item #: 161003
      Description: Powder
      Unit Size: 22.2 oz tub
      Calories/Unit: 3120
      Product Yield/Unit (fl oz): 156
      Case: 4 tubs per case
      HCPCS Code: B4158
      NDC Format Code: 00087-1466-45
    • Product: Enfamil PREMIUM Newborn
      Item #: 161005
      Description: Powder, Refill
      Unit Size: 33.2 oz box
      Calories/Unit: 4680
      Product Yield/Unit (fl oz): 234
      Case: 4 boxes per case
      HCPCS Code: B4158
      NDC Format Code: 00087-5100-42
  • Composition
    • Ingredients: Powder: Nonfat milk, lactose, vegetable oil (palm olein, coconut, soy and high oleic sunflower oils), whey protein concentrate and less than 2%: galactooligosaccharides*, polydextrose*, Mortierella alpina oil, Crypthecodinium cohnii oil, calcium carbonate, calcium phosphate, potassium citrate, magnesium oxide, ferrous sulfate, potassium chloride, zinc sulfate, sodium chloride, cupric sulfate, manganese sulfate, sodium selenite, potassium iodide, soy lecithin, vitamin A palmitate, inositol, choline chloride, ascorbic acid, niacinamide, calcium pantothenate, riboflavin, thiamin hydrochloride, vitamin D3, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, vitamin E acetate, nucleotides (cytidine 5’-monophosphate, disodium uridine 5’-monophosphate, adenosine 5’-monophosphate, disodium guanosine 5’-monophosphate), taurine, L-carnitine.

      Ingredients: Ready To Use (2 fl oz Nursette® bottle): Water, nonfat milk, lactose, vegetable oil (palm olein, soy, coconut and high oleic sunflower oils) and less than 2%: galactooligosaccharides*, polydextrose*, Mortierella alpina oil, Crypthecodinium cohnii oil, whey protein concentrate, potassium citrate, calcium phosphate, sodium chloride, calcium chloride, magnesium phosphate, calcium carbonate, ferrous sulfate, sodium citrate, zinc sulfate, cupric sulfate, potassium iodide, manganese sulfate, sodium selenite, mono- and diglycerides, ascorbic acid, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, riboflavin, thiamin hydrochloride, vitamin B6 hydrochloride, folic acid, vitamin K1, vitamin D3, biotin, vitamin B12, soy lecithin, choline chloride, carrageenan, inositol, nucleotides (cytidine 5’-monophosphate, disodium uridine 5’-monophosphate, adenosine 5’-monophosphate, disodium guanosine 5’-monophosphate), taurine, L-carnitine.

      * A type of prebiotic.

      † A source of arachidonic acid (ARA).

      ‡ A source of docosahexaenoic acid (DHA).

  • Potential Allergens
    • Enfamil PREMIUM Newborn contains milk and soy.

  • Amino Acid Composition
    • ESSENTIAL AMINO ACIDS
      mg/100 Calmg/100 g Pwd
      Histidine48250
      Isoleucine128650
      Leucine2301180
      Lysine2001000
      Methionine46240
      Cysteine48250
      Phenylalanine80410
      Tyrosine74370
      Threonine145740
      Tryptophan41210
      Valine128650
      NONESSENTIAL AMINO ACIDS
      mg/100 Calmg/100 g Pwd
      Arginine59300
      Alanine103520
      Aspartic Acid2201140
      Glutamic Acid4102100
      Glycine42210
      Proline149760
      Serine120610
      Tyrosine74370
      Threonine145740
      Tryptophan41210
      Valine128650
  • Preparation of Feedings
    • Powder

      The baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Powdered infant formulas are not sterile and should not be fed to premature infants or infants who might have immune problems unless directed and supervised by a doctor. Discuss with parents which formula is appropriate for the baby.

      Discuss with parents whether they need to use cooled, boiled water for mixing and whether they need to boil clean utensils, bottles and nipples in water before use.

      WARNING: Do not use a microwave oven to warm formula. Serious burns may result.

      Refer to the product label for the most accurate information.

      Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use formula within 1 hour or discard.

      1. Wash hands thoroughly with soap and water before preparing formula.
      2. Pour the desired amount of water into the bottle. Add powder.
      3. Cap bottle and SHAKE WELL.

      Use the following chart for correct amounts of water and powder. Use scoop in can to measure powder. Store DRY scoop in its original can.

      Enfamil Premium Newborn

      To Make*

      Water

      Powder

      Weight

      2 fl oz bottle

      2 fl oz

      1 unpacked level scoop

      9 g

      4 fl oz bottle

      4 fl oz

      2 unpacked level scoops

      18 g

      8 fl oz bottle

      8 fl oz

      4 unpacked level scoops

      36 g

    • Nursette<sup>®</sup> Bottles

      The baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Discuss with parents which formula is appropriate for the baby.

      2 fl oz Nursette Bottles

      1. Wash hands thoroughly with soap and water before preparing feeding bottles.
      2. SHAKE BOTTLE WELL, remove protective seal around cap, remove cap and foil seal.
      3. Pour into feeding bottle(s)
      4. Attach nipple unit (not included).

      WARNING: Do not use a microwave oven to warm formula. Serious burns may result.

      Failure to follow these instructions could result in severe harm. Opened bottles can spoil quickly. Either feed immediately or replace cap and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use opened bottle if it is unrefrigerated for more than a total of 2 hours. Do not freeze. After feeding begins, use formula within 1 hour or discard.

  • References
      1. Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412.
      2. Kunz C, Lönnerdal B. Re-evaluation of the whey protein/casein ratio of human milk. Acta Paediatr. 1992;81:107-112.
      3. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464.
      4. Birch EE, Khoury JC, Berseth CL, et al. The impact of early nutrition on incidence of allergic manifestations and common respiratory illnesses in children. J Pediatr. 2010;156:902-906.
      5. Scalabrin D, Mitmesser SH, Welling GW, et al. New prebiotic blend of polydextrose and galacto-oligosaccharides has a bifidogenic effect in young infants. J Pediatr Gastroenterol Nutr. 2012;54:343-352.
      6. Salminen S, Endo A, Isolauri E, et al. Early gut colonization with lactobacilli and staphylococcus in infants: the hygiene hypothesis extended. J Pediatr Gastroenterol Nutr. 2016;62:80-86.
      7. Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr. 2007; 44:359-364.
      8. Data on file.
      9. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14.
  • Consumer Reviews