Enfamil NeuroPro Infant

Milk-based, iron-fortified, routine formula for full-term infants 0–12 months.

Last Updated: Wednesday, June 27, 2018 - 18:45

Description/Indication

Enfamil NeuroPro Infant is a 20 Cal/fl oz milk-based, iron-fortified, routine formula for full-term infants 0–12 months. Enfamil NeuroPro Infant has a fat-protein blend of MFGM and DHA previously found only in breast milk*. Emerging evidence from a recent clinical study showed MFGM in formula supports cognitive development similar to breast milk. Enfamil NeuroPro Infant is patterned after mature breast milk.


* In amounts supported by clinical research.

† As measured by Bayley-III cognitive score at 12 months in a different formula with MFGM added as an ingredient.

‡ Comparison based on whey:casein ratio of typical mature breast milk (15 days to 6 months after birth)8.

Product Features:

  • Infant formula that has MFGM and DHA is clinically shown to be a safe and well-tolerated source of nutrition1
  • DHA at the clinically proven§ amount of 0.32% of total fatty acids, the same amount as the worldwide breast milk average2,||, and double the amount found in the leading competitor’s product:
    • Clinically proven§ to support mental, visual and immune system development
    • Clinically shown to improve long-term cognitive outcomes through 5 years of age3,§
    • Shown to improve respiratory health through the first 3 years of life when infants were fed through 12 months4,§
  • A Natural Defense® Dual Prebiotic blend of GOS (galactooligosaccharides) and PDX (polydextrose) at 4 g/L is designed to:
    • Support immune health by promoting the growth of beneficial bacteria (bifidobacteria and lactobacilli)5,6
    • Promote soft stools similar to those reported for breastfed infants7
  • Easy-to-digest 60:40 whey-to-casein ratio, patterned after mature breast milk8,‡
  • Inositol at the average amount found in breast milk#
  • Non-GMO**
  • Kosher

§ Studies compared infants fed Enfamil® that had DHA and ARA vs. discontinued Enfamil without DHA and ARA; studied before the addition of prebiotics.

|| Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women2.

¶ Enfamil NeuroPro Infant has not been shown superior to the leading competitor in supporting mental, visual and immune system development in infants. The level of DHA in Similac Pro-Advance is ~0.15% of total fatty acids.

# The global average total inositol amount in mature breast milk over the course of lactation is22 mg/100 kcal9.

** Ingredients not genetically engineered. Trace amounts of genetically engineered material may be present in the product, such as from manufacturing environments and process sources. For more information, visit enfamil.com/nonGMO.

  • Nutrients
    • (Normal Dilution)

      Per 100 Calories (5 fl oz)

      Per 100 mL

      Per 100 grams Powder (500 Cal)

      Protein, g

      2

      1.35

      10.2

      Fat, g

      5.3

      3.6

      27

      Linoleic acid, mg

      780

      530

      4000

      Carbohydrate, g

      11.3

      7.6

      58

      Water, g

      133

      90

      2.4

      Vitamins/Other Nutrients

      Vitamin A, IU

      300

      200

      1530

      Vitamin D, IU

      60

      41

      310

      Vitamin E, IU

      2

      1.35

      10.2

      Vitamin K, mcg

      9

      6.1

      46

      Thiamin (Vitamin B1), mcg

      80

      54

      410

      Riboflavin (Vitamin B2), mcg

      140

      95

      710

      Vitamin B6, mcg

      60

      41

      310

      Vitamin B12, mcg

      0.3

      0.2

      1.53

      Niacin, mcg

      1000

      680

      5100

      Folic acid (Folacin), mcg

      16

      10.8

      82

      Pantothenic acid, mcg

      500

      340

      2600

      Biotin, mcg

      3

      2

      15.3

      Vitamin C (Ascorbic acid), mg

      12

      8.1

      61

      Choline, mg

      24

      16.2

      122

      Inositol, mg

      24

      16.2

      122

      Minerals

      Calcium, mg

      78

      53

      400

      Phosphorus, mg

      43

      29

      220

      Magnesium, mg

      8

      5.4

      41

      Iron, mg

      1.8

      1.22

      9.2

      Zinc, mg

      1

      0.68

      5.1

      Manganese, mcg

      15

      10.1

      77

      Copper, mcg

      75

      51

      380

      Iodine, mcg

      15

      10.1

      77

      Selenium, mcg

      2.8

      1.89

      14.3

      Sodium, mg

      27

      18.3

      138

      Potassium, mg

      108

      73

      550

      Chloride, mg

      63

      43

      320

      Product nutrient values and ingredients are subject to change. Please see product label for current information.

  • Nutrient Facts
    • Nutrient Density

      20 Calories/fl oz

      Protein (% Calories)

      8

      Whey:Casein Ratio

      60:40

      Fat (% Calories)

      48

      Carbohydrate (% Calories)

      44

      Potential Renal Solute Load (mOsm/100 Calories)10

      18.6

      Potential Renal Solute Load (mOsm/100 mL)10

      12.5

      Osmolality (mOsm/kg water)

      300

      Osmolarity (mOsm/L)

      270

      Lactose-free

      No

  • Product Forms

      Enfamil NeuroPro Infant is available in powder and ready-to-use liquid.

      When using this information, please note the following:

      Coding systems and reimbursement allowable rates vary by payer:

      • Medicare Part B uses HCPCS (Healthcare Common Procedure Coding System) to group products
      • Medicaid systems vary by state; some use HCPCS while others use NDC format code or systems of their own—contact your state provider for more information
      • Private health insurance and managed care companies may use HCPCS, NDC format code or their own system—contact your provider for more information

    • Product: Enfamil NeuroPro™ Infant
      Item #: 897205
      Description: Powder, Refill
      Unit Size: 31.4 oz box
      Calories/Unit: 4500
      Product Yield/Unit (fl oz): 225
      Case: 4 boxes per case
      HCPCS Code: B4158
      NDC Format Code: 00087-5121-11
    • Product: Enfamil NeuroPro Infant
      Item #: 897206
      Description: Powder
      Unit Size: 8 oz can
      Calories/Unit:
      Product Yield/Unit (fl oz):
      Case: 6 Cans
      HCPCS Code: B4158
      NDC Format Code: 00087-5121-06
    • Product: Enfamil NeuroPro Infant
      Item #: 897204
      Description: Powder
      Unit Size: 20.7 oz tub
      Calories/Unit: 2960
      Product Yield/Unit (fl oz): 148
      Case: 6 tubs per case
      HCPCS Code: B4158
      NDC Format Code: 00087-5121-07
    • Product: Enfamil NeuroPro Infant
      Item #: 897202
      Description: Single-Serve Powder Packets
      Unit Size: 17.6 g stick packs (14 per carton)
      Calories/Unit: 1120
      Product Yield/Unit (fl oz): 56
      Case: 4 cartons per case
      HCPCS Code: B4158
      NDC Format Code: 00087-5121-03
    • Product: Enfamil NeuroPro Infant
      Item #: 171602
      Description: RTU
      Unit Size: 2 fl oz bottle
      Calories/Unit: 40
      Product Yield/Unit (fl oz): 2
      Case: 48 bottles per case
      HCPCS Code: B4158
      NDC Format Code: 00087-5121-29
    • Product: Enfamil NeuroPro Infant
      Item #: 171901
      Description: RTU
      Unit Size: 6 fl oz bottle
      Calories/Unit: 120
      Product Yield/Unit (fl oz): 6
      Case: 24 bottles per case
      HCPCS Code: B4158
      NDC Format Code: 00087-5121-33
    • Product: Enfamil NeuroPro Infant
      Item #: 897405
      Description: RTU
      Unit Size: 32 fl oz bottle
      Calories/Unit: 640
      Product Yield/Unit (fl oz): 32
      Case: 6 bottles per case
      HCPCS Code: B4158
      NDC Format Code: 00087-5121-41
  • Composition
    • Ingredients: Powder: Nonfat milk, lactose, vegetable oil (palm olein, coconut, soy and high oleic sunflower oils), whey protein concentrate, whey protein-lipid concentrate (milk)* and less than 2%: galactooligosaccharides, polydextrose, Mortierella alpina oil, Schizochytrium sp. oil§, calcium carbonate, potassium citrate, potassium chloride, ferrous sulfate, calcium phosphate, sodium chloride, magnesium oxide, zinc sulfate, cupric sulfate, manganese sulfate, potassium iodide, sodium selenite, soy lecithin, inositol, choline chloride, ascorbic acid, niacinamide, calcium pantothenate, vitamin A palmitate, riboflavin, thiamin hydrochloride, vitamin D3, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, vitamin E acetate, nucleotides (cytidine 5’-monophosphate, disodium uridine 5’-monophosphate, adenosine 5’-monophosphate, disodium guanosine 5’-monophosphate), taurine, L-carnitine.

      Ingredients: Ready To Use (2 & 6 fl oz Nursette® bottles): Water, nonfat milk, lactose, vegetable oil (palm olein, soy, coconut and high oleic sunflower oils) and less than 2%: whey protein-lipid concentrate (milk)* galactooligosaccharides, polydextrose, Mortierella alpina oil, Schizochytrium sp. oil§, whey protein concentrate, potassium citrate, calcium carbonate, calcium phosphate, magnesium phosphate, calcium chloride, sodium chloride, ferrous sulfate, zinc sulfate, cupric
      sulfate, manganese sulfate, potassium iodide, sodium selenite, mono- and diglycerides, ascorbic acid, sodium ascorbate, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, thiamin hydrochloride, riboflavin, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin D3, vitamin B12, soy lecithin, carrageenan, choline chloride, inositol, nucleotides (cytidine 5’-monophosphate, disodium uridine 5’-monophosphate, adenosine 5’-monophosphate, disodium guanosine 5’-monophosphate), taurine, L-carnitine.

      Ingredients: Ready To Use (32 fl oz bottle||) Water, nonfat milk, lactose, vegetable oil (palm olein, soy, coconut and high oleic sunflower oils) and less than 2%: whey protein-lipid concentrate (milk)*, galactooligosaccharides, polydextrose, Mortierella alpina oil, Schizochytrium sp. oil§, whey protein concentrate, potassium citrate, calcium carbonate, calcium chloride, magnesium phosphate, sodium chloride, calcium phosphate, ferrous sulfate, zinc sulfate, cupric sulfate, manganese sulfate, sodium selenite, potassium iodide, mono- and diglycerides, soy lecithin, ascorbic acid, sodium ascorbate, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, thiamin hydrochloride, riboflavin, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, carrageenan, choline chloride, inositol, nucleotides (cytidine 5’-monophosphate, adenosine 5’-monophosphate, disodium uridine 5’-monophosphate, disodium guanosine 5’-monophosphate), vitamin D3, taurine, L-carnitine.


      * A source of MFGM (milk fat globule membrane).

      † A type of prebiotic.

      ‡ A source of arachidonic acid (ARA).

      § A source of docosahexaenoic acid (DHA).

      || Nutrient profile subject to change.

  • Potential Allergens
    • Enfamil NeuroPro Infant contains milk and soy.

  • Preparation of Feedings
    • Powder

      The baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Powdered infant formulas are not sterile and should NOT be fed to premature infants or infants who might have immune problems unless directed and supervised by a doctor. Discuss with parents which formula is appropriate for the baby.

      Discuss with parents whether they need to use cooled, boiled water for mixing and whether they need to boil clean utensils, bottles and nipples in water before use.

      WARNING: Do not use a microwave oven to warm formula. Serious burns may result.

      Refer to the product label for the most accurate information.

      Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use formula within 1 hour or discard.

      1. Wash hands thoroughly with soap and water before preparing formula.
      2. Pour the desired amount of water into the bottle. Add powder.
      3. Cap bottle and SHAKE WELL.

      Use the following chart for correct amounts of water and powder.

      Enfamil NeuroPro Infant

      To Make*

      Water

      Powder

      Weight

      2 fl oz bottle

      2 fl oz

      1 unpacked level scoop

      8.8 g

      4 fl oz bottle

      4 fl oz

      2 unpacked level scoops

      17.6 g

      8 fl oz bottle

      8 fl oz

      4 unpacked level scoops

      35.2 g

      * Each scoop adds about 0.2 fl oz to the amount of prepared formula.

    • Ready-to-use

      The baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Discuss with parents which formula is appropriate for the baby.

      2 & 6 fl oz Nursette® Bottles

      1. Inspect each bottle for signs of damage.
      2. Wash hands thoroughly with soap and water before preparing bottle for feeding.
      3. SHAKE BOTTLE WELL and remove cap.
      4. Attach nipple unit (not included).

      WARNING: Do not use a microwave oven to warm formula. Serious burns may result.

      Failure to follow these instructions could result in severe harm. Opened bottles can spoil quickly. Either feed immediately or replace cap and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use opened bottle if it is unrefrigerated for more than a total of 2 hours. Do not freeze. After feeding begins, use formula within 1 hour or discard.

      32 fl oz Bottles

      1. Wash hands thoroughly with soap and water before preparing feeding bottles.
      2. SHAKE BOTTLE WELL, remove protective seal around cap, remove cap and foil seal. Replace cap.
      3. Pour into feeding bottle(s).

      WARNING: Do not use a microwave oven to warm formula. Serious burns may result.

      Failure to follow these instructions could result in severe harm. Opened bottles and prepared formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 48 hours. Do not use opened bottle and/or prepared formula if they are unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use prepared formula within 1 hour or discard.

    • Single Serve Powder Packets

      The baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Discuss with parents which formula is appropriate for the baby.

      1. Wash hands thoroughly with soap and water before preparing formula.
      2. Pour desired amount of water into bottle. Pour entire contents of packet(s) into bottle.
      3. Cap bottle and SHAKE WELL.

      WARNING: Do not use a microwave oven to warm formula. Serious burns may
      result.

      Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use formula within 1 hour or discard.

      Use the chart below for correct amounts of water and powder.

      Enfamil NeuroPro Infant

      To Make*

      Water

      Powder

      Weight

      4 fl oz bottle

      4 fl oz

      1 packet

      17.6 g

      8 fl oz bottle

      8 fl oz

      2 packets

      35.2 g

      * Each packet adds about 0.4 fl oz to the amount of prepared formula.

  • References
      1. Timby N, Domellöf E, Hernell O, et al. Neurodevelopment, nutrition, and growth until 12 mo of age in infants fed a low-energy, low-protein formula supplemented with bovine milk fat globule membranes: a randomized controlled trial. Am J Clin Nutr. 2014;99:860-868.
      2. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464.
      3. Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412.
      4. Birch EE, Khoury JC, Berseth CL, et al. The impact of early nutrition on incidence of allergic manifestations and common respiratory illnesses in children. J Pediatr. 2010;156:902-906.
      5. Scalabrin D, Mitmesser SH, Welling GW, et al. New prebiotic blend of polydextrose and galacto-oligosaccharides has a bifidogenic effect in young infants. J Pediatr Gastroenterol Nutr. 2012;54:343-352.
      6. Salminen S, Endo A, Isolauri E, et al. Early gut colonization with lactobacilli and staphylococcus in infants: the hygiene hypothesis extended. J Pediatr Gastroenterol Nutr. 2016;62:80-86.
      7. Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr. 2007;44:359-364.
      8. Kunz C, Lönnerdal B. Re-evaluation of the whey protein/casein ratio of human milk. Acta Paediatr. 1992;81:107-112.
      9. Data on file.
      10. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14.
  • Consumer Reviews