Enfamil® Enspire

Milk-based powder with iron with two new ingredients: MFGM to foster cognitive development and lactoferrin to support immune health.

Last Updated: Thursday, October 26, 2017 - 20:00

Description/Indication

Enfamil Enspire is a 20 Cal/fl oz milk-based, iron-fortified, routine formula for full-term infants 0–12 months. Enfamil Enspire has two components previously only largely available in breast milk: MFGM to foster cognitive development and lactoferrin to support immune health.

Product Features:

  • Milk fat globule membrane (MFGM) provides the brain-building advantages of breast milk and is shown to improve cognitive outcomes at 12 months1
  • Lactoferrin supports immune health and brings Enfamil® composition closer to human milk than ever before2
  • DHA at the clinically proven* amount of 0.32% of total fatty acids, the same amount as the worldwide breast milk average3,†, and double the amount found in the leading competitors product
    • Clinically proven* to support mental, visual and immune system development
    • Clinically shown to improve long-term cognitive outcomes through 5 years of age4,*
    • Shown to improve respiratory health through the first 3 years of life when infants were fed through 12 months5,*
  • A Natural Defense® Dual Prebiotic blend of GOS (galactooligosaccharides) and PDX (polydextrose) at 4 g/L is clinically proven to:
    • Support immune health by promoting the growth of beneficial bacteria (bifidobacteria and lactobacilli)6,7
    • Promote soft stools similar to those reported for breastfed infants8
  • Proprietary Triple Health Guard® blend of brain-nourishing DHA, an exclusive dual prebiotic blend and 30 total nutrients for growth
  • Supports excellent growth
  • Easy-to-digest 60:40 whey-to-casein ratio, patterned after mature breast milk9,§
  • Non-GMO||
  • Kosher


* Studies compared infants fed Enfamil with DHA and ARA vs. discontinued Enfamil without DHA and ARA; studied before the addition of prebiotics.
† Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women3.
‡ Enfamil Enspire has not been shown superior to the leading competitor in supporting mental, visual and immune system development. The level of DHA in Similac Pro-Advance is ~0.15% of total fatty acids.
§ Comparison based on whey-to-casein ratio of typical mature breast milk (15 days to 6 months after birth).
|| Ingredients not genetically engineered. Trace amounts of genetically engineered material may be present in the product, such as from manufacturing environments and process sources. For more information, visit enfamil.com/nonGMO.

  • Nutrients
    • (Normal Dilution)

      Per 100 Calories (5 fl oz)

      Per 100 mL

      Per 100 grams Powder (500 Cal)

      Protein, g

      2.1

      1.42

      10.5

      Fat, g

      5.3

      3.6

      27

      Linoleic acid, mg

      800

      540

      4000

      Carbohydrate, g

      11.2

      7.6

      56

      Water, g

      133

      90

      2.8

      Vitamins/Other Nutrients

      Vitamin A, IU

      300

      200

      1500

      Vitamin D, IU

      60

      41

      300

      Vitamin E, IU

      2

      1.35

      10

      Vitamin K, mcg

      9

      6.1

      45

      Thiamin (Vitamin B1), mcg

      80

      54

      400

      Riboflavin (Vitamin B2), mcg

      140

      95

      700

      Vitamin B6, mcg

      60

      41

      300

      Vitamin B12, mcg

      0.3

      0.2

      1.5

      Niacin, mcg

      1000

      680

      5000

      Folic acid (Folacin), mcg

      16

      10.8

      80

      Pantothenic acid, mcg

      500

      340

      2500

      Biotin, mcg

      3

      2

      15

      Vitamin C (Ascorbic acid), mg

      12

      8.1

      60

      Choline, mg

      24

      16.2

      120

      Inositol, mg

      6

      4.1

      30

      Minerals

      Calcium, mg

      78

      53

      390

      Phosphorus, mg

      43

      29

      220

      Magnesium, mg

      8

      5.4

      40

      Iron, mg

      1.8

      1.22

      9

      Zinc, mg

      1

      0.68

      5

      Manganese, mcg

      15

      10.1

      75

      Copper, mcg

      75

      51

      380

      Iodine, mcg

      15

      10.1

      75

      Selenium, mcg

      2.8

      1.89

      14

      Sodium, mg

      27

      18.3

      135

      Potassium, mg

      108

      73

      540

      Chloride, mg

      63

      43

      320

      Product nutrient values and ingredients are subject to change. Please see product label for current information.

  • Nutrient Facts
    • Nutrient Density

      20 Calories/fl oz

      Protein (% Calories)

      8.5

      Whey:Casein Ratio

      60:40

      Fat (% Calories)

      48

      Carbohydrate (% Calories)

      43.5

      Potential Renal Solute Load (mOsm/100 Calories)10

      19.1

      Potential Renal Solute Load (mOsm/100 mL)10

      12.9

      Osmolality (mOsm/kg water)

      300

      Osmolarity (mOsm/L)

      270

      Lactose-free

      No

  • Product Forms

      Enfamil® Enspire is available in powder.

      When using this information, please note the following:

      Coding systems and reimbursement allowable rates vary by payer:

      • Medicare Part B uses HCPCS (Healthcare Common Procedure Coding System) to group products
      • Medicaid systems vary by state; some use HCPCS while others use NDC format code or systems of their own—contact your state provider for more information
      • Private health insurance and managed care companies may use HCPCS, NDC format code or their own system—contact your provider for more information


    • Product: Enfamil®Enspire
      Item #: 157401
      Description: Powder
      Unit Size: 20.5 oz tub
      Calories/Unit: 2940
      Product Yield/Unit (fl oz): 147
      Case: 4 tubs per case
      HCPCS Code: B4158
      NDC Format Code: 00087-5117-48
  • Composition
    • Ingredients: Nonfat milk, lactose, vegetable oil (palm olein, coconut, soy and high oleic sunflower oils), whey protein-lipid concentrate* (milk), whey protein concentrate and less than 2%: lactoferrin, galactooligosaccharides, polydextrose, Mortierella alpina oil, Crypthecodinium cohnii oil§, potassium citrate, calcium carbonate, calcium phosphate, sodium chloride, potassium chloride, ferrous sulfate, magnesium oxide, zinc sulfate, cupric sulfate, manganese sulfate, potassium iodide, sodium selenite, soy lecithin, choline chloride, ascorbic acid, niacinamide, calcium pantothenate, riboflavin, thiamin hydrochloride, vitamin D3, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, inositol, vitamin E acetate, vitamin A palmitate, nucleotides (cytidine 5’-monophosphate, disodium uridine 5’-monophosphate, adenosine 5’-monophosphate, disodium guanosine 5’-monophosphate), taurine, L-carnitine.

      * A source of MFGM (milk fat globule membrane).
      † A type of prebiotic.
      ‡ A source of arachidonic acid (ARA).
      § A source of docosahexaenoic acid (DHA).

  • Potential Allergens
    • Enfamil Enspire contains milk and soy.

  • Preparation of Feedings
    • Powder

      The baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Powdered infant formulas are not sterile and should NOT be fed to premature infants or infants who might have immune problems unless directed and supervised by a doctor. Discuss with parents which formula is appropriate for the baby.

      Discuss with parents whether they need to use cooled, boiled water for mixing and whether they need to boil clean utensils, bottles and nipples in water before use.

      WARNING: Do not use a microwave oven to warm formula. Serious burns may result.

      Refer to the product label for the most accurate information.

      Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use formula within 1 hour or discard.

      1. Wash hands thoroughly with soap and water before preparing formula.
      2. Pour the desired amount of water into the bottle. Add powder.
      3. Cap bottle and SHAKE WELL.

      Use the following chart for correct amounts of water and powder. Use scoop in tub or can to measure powder. Store DRY scoop in lid holder in tub or in can.

      Enfamil Enspire

      To Make*

      Water

      Powder

      Weight

      2 fl oz bottle

      2 fl oz

      1 unpacked level scoop

      8.8 g

      4 fl oz bottle

      4 fl oz

      2 unpacked level scoops

      17.6 g

      8 fl oz bottle

      8 fl oz

      4 unpacked level scoops

      35.2 g

      * Each scoop adds about 0.2 fl oz to the amount of prepared formula.

  • References
      1. Timby N, Domellöf E, Hernell O, et al. Neurodevelopment, nutrition, and growth until 12 mo of age in infants fed a low-energy, low-protein formula supplemented with bovine milk fat globule membranes: a randomized controlled trial. Am J Clin Nutr 2014;99:860-868.
      2. King JC Jr, Cummings GE, Guo N, et al. A double-blind, placebo-controlled, pilot study of bovine lactoferrin supplementation in bottle-fed infants. J Pediatr Gastroenterol Nutr. 2007;44:245-251
      3. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464.
      4. Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412.
      5. Birch EE, Khoury JC, Berseth CL, et al. The impact of early nutrition on incidence of allergic manifestations and common respiratory illnesses in children. J Pediatr. 2010;156:902-906.
      6. Scalabrin D, Mitmesser SH, Welling GW, et al. New prebiotic blend of polydextrose and galacto-oligosaccharides has a bifidogenic effect in young infants. J Pediatr Gastroenterol Nutr. 2012;54:343-352.
      7. Salminen S, Endo A, Isolauri E, et al. Early gut colonization with lactobacilli and staphylococcus in infants: the hygiene hypothesis extended. J Pediatr Gastroenterol Nutr. 2016;62:80-86.
      8. Ziegler E, Vanderhoof JA, Petschow B et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr. 2007;44:359-364.
      9. Kunz C, Lönnerdal B. Re-evaluation of the whey protein/casein ratio of human milk. Acta Paediatr. 1992;81:107-112.
      10. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14.

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