Enfamil® Premature 24 Cal

Milk-based infant formulas for premature or low-birth-weight infants

Last Updated: Monday, December 18, 2017 - 19:00

Description/Indication Enfamil Premature 24 Cal is a milk-based infant formula specifically formulated to meet the unique nutritional needs of rapidly growing premature or low-birth-weight infants who do not receive human milk*. The Enfamil Premature Nutrition portfolio is the only premature infant formula line designed to meet the latest Global Expert Recommendations for all labeled nutrients. Protein is a major driver of lean mass growth and neuro-cognitive outcomes, and Enfamil Premature Nutrition supports these protein needs. When more than 12 fl oz (355 mL) of 24 Calories/fl oz product is used per day, which may occur in larger infants weighing over 2500 g (5.5 lbs) consuming only Enfamil Premature, intake of some nutrients (eg, fat soluble vitamins) may be excessive. In such circumstances, it should be used only at the direction and under the supervision of a doctor. Enfamil® EnfaCare® may be a product to consider in such circumstances.

Product Features:

  • Meets 2014 Global Expert Recommendations for 100% of all labeled nutrients1
  • 3.3 g of protein/100 Calories—appropriate for growth and development1-3
  • 80:20 whey-to-casein ratio patterned after early human milk
  • Calcium, phosphorus and vitamin D within the ranges recommended by experts to help support bone mineralization and growth1:
    • Calcium:phosphorus ratio = 1.83:1
  • DHA at 0.34% of total fatty acids, similar to the worldwide breast milk average4,‡, to help support brain and eye development and to help support blood DHA concentration5
  • Fat blend is 40% medium-chain triglycerides (MCT) oil to promote fat absorption6,7
  • Carbohydrate blend of 60% corn syrup solids (glucose polymers) and 40% lactose blend that is easily digested and helps avoid overloading the premature infant's capacity to digest lactose
  • Provides approximately 2 mg iron/kg body weight when fed at 120 Cal/kg body weight per day
  • Kosher, Halal


* Increased caloric density, protein, and some vitamins and minerals compared to standard term formula to help support weight and growth in babies born prematurely.

† Whey-to-casein ratio 3-5 days after lactation begins.

‡ Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women4.

  • Nutrients
    • (Normal Dilution)

      Per 100 Calories

      Per 100 mL

      Protein, g

      3.3

      2.7

      Fat, g

      5

      4.1

      Linoleic acid, mg

      810

      660

      Carbohydrate, g

      10.8

      8.8

      Water, g

      108

      88

      Vitamins/Other Nutrients

      Vitamin A, IU

      1350

      1100

      Vitamin D, IU

      300

      240

      Vitamin E, IU

      6.3

      5.1

      Vitamin K, mcg

      9

      7.3

      Thiamin (Vitamin B1), mcg

      200

      162

      Riboflavin (Vitamin B2), mcg

      300

      240

      Vitamin B6, mcg

      150

      122

      Vitamin B12, mcg

      0.25

      0.2

      Niacin, mcg

      4000

      3200

      Folic acid (Folacin), mcg

      40

      32

      Pantothenic acid, mcg

      1200

      970

      Biotin, mcg

      4

      3.2

      Vitamin C (Ascorbic acid), mg

      20

      16.2

      Choline, mg

      24

      19.5

      Inositol, mg

      44

      36

      Minerals

      Calcium, mg

      165

      134

      Phosphorus, mg

      90

      73

      Magnesium, mg

      9

      7.3

      Iron, mg

      1.8

      1.46

      Zinc, mg

      1.5

      1.22

      Manganese, mcg

      6.3

      5.1

      Copper, mcg

      120

      97

      Iodine, mcg

      25

      20

      Selenium, mcg

      5

      4.1

      Sodium, mg

      70

      57

      Potassium, mg

      98

      80

      Chloride, mg

      106

      86

      Product nutrient values and ingredients are subject to change. Please see product label for current information.

  • Nutrient Facts
    • Nutrient Density

      24 Calories/fl oz

      Protein (% Calories)

      13

      Whey:Casein Ratio

      80:20

      Fat (% Calories)

      44

      Carbohydrate (% Calories)

      43

      Potential Renal Solute Load (mOsm/100 Calories)8

      30

      Potential Renal Solute Load (mOsm/100 mL)8

      25

      Osmolality (mOsm/kg water)

      320

      Osmolarity (mOsm/L)

      280

      Lactose-free

      No

  • Product Forms

      Enfamil® Premature 24 Cal is available in ready-to-use Nursette® bottles.

      When using this information, please note the following:

      Coding systems and reimbursement allowable rates vary by payer:

      • Medicare Part B uses HCPCS (Healthcare Common Procedure Coding System) to group products
      • Medicaid systems vary by state; some use HCPCS while others use NDC format code or systems of their own—contact your state provider for more information
      • Private health insurance and managed care companies may use HCPCS, NDC format code or their own system—contact your provider for more information

    • Product: Enfamil® Premature 24 Cal
      Item #: 156301
      Description: RTU, 24 Cal
      Unit Size: 2 fl oz bottle
      Calories/Unit: 48
      Product Yield/Unit (fl oz): 2
      Case: 48 bottles per case
      HCPCS Code: B4160
      NDC Format Code: 00087-5115-68
  • Composition
    • Ingredients: Ready To Use (2 fl oz Nursette bottles): Water, nonfat milk, corn syrup solids, whey protein concentrate, lactose, medium chain triglycerides (MCT oil), soy oil, high oleic sunflower oil and less than 0.5%: Mortierella alpina oil*, Crypthecodinium cohnii oil, calcium phosphate, calcium hydroxide, potassium citrate, sodium chloride, calcium carbonate, magnesium phosphate, calcium chloride, potassium chloride, ferrous sulfate, zinc sulfate, cupric sulfate, potassium iodide, sodium selenite, rice starch, sodium ascorbate, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, thiamin hydrochloride, riboflavin, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, mono- and diglycerides, inositol, soy lecithin, choline chloride, vitamin D3, nucleotides (cytidine 5’-monophosphate, disodium uridine 5’-monophosphate, adenosine 5’-monophosphate, disodium guanosine 5’-monophosphate), taurine, L-carnitine.

      * A source of arachidonic acid (ARA).

      † A source of docosahexaenoic acid (DHA).

  • Potential Allergens
    • Enfamil Premature 24 Cal contains milk and soy.

  • Amino Acid Composition
    • ESSENTIAL AMINO ACIDS
      mg/100 Calmg/100 g Pwd
      Histidine76
      Isoleucine200
      Leucine360
      Lysine310
      Methionine73
      Cysteine76
      Phenylalanine125
      Tyrosine116
      Threonine230
      Tryptophan64
      Valine200
      NONESSENTIAL AMINO ACIDS
      mg/100 Calmg/100 g Pwd
      Arginine92
      Alanine162
      Aspartic Acid350
      Glutamic Acid640
      Glycine66
      Proline230
      Serine188
      Tyrosine116
      Threonine230
      Tryptophan64
      Valine200
  • Preparation of Feedings
    • Nursette<sup>®</sup> Bottles

      The baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Discuss with parents which formula is appropriate for the baby.

      2 fl oz Bottles

      1. Inspect each bottle for signs of damage.
      2. Wash hands thoroughly with soap and water before preparing bottle for feeding.
      3. SHAKE BOTTLE WELL and remove cap.
      4. Attach nipple unit (not included).

      Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use formula within 1 hour or discard.

      CAUTION: This product should be used only as directed by the baby’s doctor.

  • References
      1. Koletzko B, Poindexter B, Uauy R (eds). Nutritional Care of Preterm Infants: Scientific Basis and Practice Guidelines. World Rev Nutr Diet. Basel, Karger, 2014; 110:1-314.
      2. Klein CJ. Nutrient requirements for preterm infant formulas. J Nutr. 2002;132(suppl):1395S-1577S.
      3. Agostoni C, Buonocore G, Carnielli VP, et al. Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2010;50:85-91.
      4. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464.
      5. Innis SM, Adamkin DH, Hall RT, et al. Docosahexaenoic acid and arachidonic acid enhance growth with no adverse effects in preterm infants fed formula. J Pediatr. 2002;140:547-554.
      6. Tantibhedhyangkul P, Hashim SA. Medium-chain triglyceride feeding in premature infants: effects on fat and nitrogen absorption. Pediatrics. 1975;55:359-370.
      7. Andrews BF, Lorch V. Improved fat and Ca absorption in LBW infants fed a medium-chain triglyceride containing formula [abstract]. Pediatr Res. 1974;8:104.
      8. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14.
  • Consumer Reviews