Enfamil® Human Milk Fortifier Powder

Nutritional supplement to be added to expressed breast milk for premature or low-birth-weight infants

Last Updated: Sunday, January 7, 2018 - 19:00


Enfamil Human Milk Fortifier Powder is to be added to expressed breast milk for feeding premature or low-birth-weight infants. It provides enriched nutrition needed by these special babies while still allowing them to receive their mother’s milk. Enfamil Human Milk Fortifier Powder is milk-based and, when mixed with mother’s milk, increases the levels of protein, energy, calcium, phosphorus and other nutrients, producing a diet more suited to the nutritional needs of the rapidly growing premature infant.

Enfamil Human Milk Fortifier Powder was specifically designed to be used as a supplement to be added to mother’s milk collected after 2 weeks postpartum.

Product Features:

  • Well tolerated
  • 1.1 g protein/4 packets
  • Added iron to reduce the need for additional iron supplementation
  • Includes fat and essential fatty acids
  • Low osmolality
  • Kosher, Halal
  • Nutrients
    • (4 Packets)

      Per 4–0.025 oz (0.71 g) Packets (14 Cal)

      Protein, g


      Fat, g


      Linoleic acid, mg


      alpha-Linolenic acid, mg


      Carbohydrate, g

      < 0.4

      Water, g


      Vitamins/Other Nutrients

      Vitamin A, IU


      Vitamin D, IU


      Vitamin E, IU


      Vitamin K, mcg


      Thiamin (Vitamin B1), mcg


      Riboflavin (Vitamin B2), mcg


      Vitamin B6, mcg


      Vitamin B12, mcg


      Niacin, mcg


      Folic acid (Folacin), mcg


      Pantothenic acid, mcg


      Biotin, mcg


      Vitamin C (Ascorbic acid), mg



      Calcium, mg


      Phosphorus, mg


      Magnesium, mg


      Iron, mg


      Zinc, mg


      Manganese, mcg


      Copper, mcg


      Sodium, mg


      Potassium, mg


      Chloride, mg


      Product nutrient values and ingredients are subject to change. Please see product label for current information.

  • Nutrient Facts
    • Nutrient Density

      Per 4 Packets (14 Cal)

      Protein (% Calories)


      Fat (% Calories)


      Carbohydrate (% Calories)


      Potential Renal Solute Load (mOsm)1

      29 per 100 Calories

      Potential Renal Solute Load (mOsm)1

      9.8 per 4 packets*

      Osmolality (mOsm/kg water)


      Osmolarity (mOsm/L)

      Not available



      * 23 mOsm/102 mL when 4 packets added to 100 mL preterm human milk.

      † When added to human milk as recommended, EHMF Powder increases osmolality by approximately 35 mOsm/kg water.

  • Product Forms

      Enfamil Human Milk Fortifier Powder is available in powder.

      When using this information, please note the following:

      Coding systems and reimbursement allowable rates vary by payer:

      • Medicare Part B uses HCPCS (Healthcare Common Procedure Coding System) to group products
      • Medicaid systems vary by state; some use HCPCS while others use NDC format code or systems of their own—contact your state provider for more information
      • Private health insurance and managed care companies may use HCPCS, NDC format code or their own system—contact your provider for more information

    • Product: Enfamil® Human Milk Fortifier Powder
      Item #: 201418
      Description: Powder
      Unit Size: 0.71 g foil sachet
      Calories/Unit: 3.5
      Product Yield/Unit (fl oz): —
      Case: 200 units per case
      HCPCS Code: B4155
      NDC Format Code: 00087-2014-48
  • Composition
    • Ingredients: Powder: Medium-chain triglycerides (MCT) oil, milk protein isolate, whey protein isolate hydrolysate, soybean oil, calcium phosphate, calcium glycerophosphate, calcium gluconate and less than 2%: corn syrup solids, soy lecithin, vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, thiamin hydrochloride, riboflavin, vitamin B6 hydrochloride, vitamin B12, niacinamide, folic acid, calcium pantothenate, biotin, ascorbic acid, magnesium phosphate, potassium phosphate, ferrous sulfate, zinc sulfate, cupric sulfate, sodium citrate, potassium chloride, potassium citrate.

  • Potential Allergens
    • Enfamil Human Milk Fortifier Powder contains milk and soy.

  • Preparation of Feedings
    • Human Milk Fortifiers

      The baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional.

      Improper hygiene, preparation, dilution, use or storage may result in severe harm. Although Enfamil® Human Milk Fortifier Powder is formulated for premature infants, nutritional powders are not sterile and should NOT be fed to premature infants or infants who might have immune problems unless directed and supervised by a doctor.

      • Follow hospital rules or the baby’s doctor’s instructions for the safe handling of human milk.
      • To aid mixing, agitate the human milk well. Pour the desired amount into a sterile container and warm to feeding temperature.
      • The baby’s doctor will provide instructions for the desired amount of calories to add.
      • Add the powder to the human milk according to the following chart:

      Additional Calories Desired

      Human Milk

      Enfamil Human Milk Fortifier

      2 Calories/fl oz

      50 mL

      1 packet (0.71 g)

      4 Calories/fl oz

      25 mL

      1 packet (0.71 g)

      Failure to follow these instructions could result in severe harm. Once prepared, fortified breast milk can spoil quickly. Either feed fortified human milk immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Agitate before each use.

      For bottle feeding: Pour only the amount of fortified human milk to be fed into a feeding container and feed immediately. Do not use fortified human milk if it is unrefrigerated for more than a total of 2 hours. After feeding begins, use fortified human milk within 1 hour or discard.

      For tube feeding: Once fortified human milk is prepared, it can remain at room temperature for no longer than a total of 4 hours.

      WARNING: Do not use a microwave oven to warm the fortified human milk. Serious burns may result.

      CAUTION: Nutritionally incomplete. To be used only under the supervision of a physician.

      Regarding use in extremely low-birth-weight infants (ELBW–1 kg or less): Hypercalcemia has been reported in some of these infants on full enteral feeds of mothers’ milk supplemented with human milk fortifiers.

      For post-discharge preterm babies up to 4.5kg (9.9 lbs): Usage should not exceed fortifying more than 100 mL breastmilk per kg body weight/day at the 22 Cal/fl oz dilution.

  • References
      1. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute in infancy. J Pediatr. 1999;134:11-14.
  • Consumer Reviews