• Enfamil PREMIUM® Newborn 22.2 oz Tub
  • Enfamil PREMIUM® Newborn 2 oz bottle
  • Enfamil PREMIUM® Newborn 33.2 oz refill box

Enfamil PREMIUM® Newborn

20 Cal/fl oz milk-based, iron-fortified formula for full-term newborns through 3 months

Last Updated: Thursday, October 26, 2017

  • Description/Indication
    • Enfamil PREMIUM Newborn is a 20 Cal/fl oz milk-based, iron-fortified formula for full-term newborns through 3 months. Enfamil PREMIUM Newborn has DHA in amounts clinically demonstrated to foster cognitive development through 5 years of age1,*. Enfamil PREMIUM Newborn is patterned after early breast milk2,† with an 80:20 whey-to-casein ratio and is designed for newborns. Enfamil PREMIUM Newborn meets American Academy of Pediatrics (AAP) recommendations for vitamin D intake by providing 400 IU of vitamin D in just 27 fl oz—the approximate daily intake of a newborn. Enfamil PREMIUM Newborn offers outcomes in 3 key areas: brain development, immune health and growth.

  • Product Features
      • DHA at the clinically proven* amount of 0.32% of total fatty acids, the same amount as the worldwide breast milk average3,‡, and double the amount found in the leading competitor’s product§:
        • Clinically proven* to support mental, visual and immune system development
        • Clinically shown to improve long-term cognitive outcomes through 5 years of age1,*
        • Shown to improve respiratory health through the first 3 years of life when infants were fed through 12 months4,*
      • A Natural Defense® Dual Prebiotic blend of GOS (galactooligosaccharides) and PDX (polydextrose) at 4 g/L is clinically proven to:
        • Support immune health by promoting the growth of beneficial bacteria (bifidobacteria and lactobacilli)5,6
        • Promote soft stools similar to those reported for breastfed infants7
      • Proprietary Triple Health Guard® blend of brain-nourishing DHA, an exclusive dual prebiotic blend and 30 total nutrients for growth
      • Easy-to-digest, 80:20 whey-to-casein protein blend patterned after early breast milk2,†
      • Provides 400 IU of vitamin D in just 27 fl oz
      • Inositol at the average amount found in breast milk||
      • Nucleotides to help support the developing immune system
      • Non-GMO
      • Kosher

      * Studies compared infants fed Enfamil® with DHA and ARA vs. discontinued Enfamil without DHA and ARA; studied before the addition of prebiotics.
      † Based on whey:casein ratio 3-5 days after lactation begins.
      ‡ Average level of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women3.
      § Enfamil PREMIUM Newborn has not been shown superior to the leading competitor in supporting mental, visual and immune system development.
      || The global average total inositol level in mature breast milk over the course of lactation is 22 mg/100 kcal8.
      ¶ Ingredients not genetically engineered. Trace amounts of genetically engineered material may be present in the product, such as from manufacturing environments and process sources. For more information, visit enfamil.com/nonGMO.

  • Nutrients
    • Product nutrient values and ingredients are subject to change. Please see product label for current information.

      (Normal Dilution) Per 100 Calories
      (5 fl oz)
      Per 100 mL Per 100 grams
      Powder (510 Cal)
      Protein, g 2.1 1.42 10.7
      Fat, g 5.3 3.6 27
      Linoleic acid, mg 780 530 4000
      Carbohydrate, g 11.2 7.6 57
      Water, g 133 90 2
      (Normal Dilution) Per 100 Calories
      (5 fl oz)
      Per 100 mL Per 100 grams
      Powder (510 Cal)
      Vitamins/Other Nutrients
      Vitamin A, IU 300 200 1530
      Vitamin D, IU 75 51 380
      Vitamin E, IU 2 1.35 10.2
      Vitamin K, mcg 9 6.1 46
      Thiamin (Vitamin B1), mcg 80 54 410
      Riboflavin (Vitamin B2), mcg 140 95 710
      Vitamin B6, mcg 60 41 310
      Vitamin B12, mcg 0.3 0.2 1.53
      Niacin, mcg 1000 680 5100
      Folic acid (Folacin), mcg 16 10.8 82
      Pantothenic acid, mcg 500 340 2600
      Biotin, mcg 3 2 15.3
      Vitamin C (Ascorbic acid), mg 12 8.1 61
      Choline, mg 24 16.2 122
      Inositol, mg 24 16.2 122
      L-carnitine, mg 2 1.35 10.2
      Taurine, mg 6 4.1 31
      (Normal Dilution) Per 100 Calories
      (5 fl oz)
      Per 100 mL Per 100 grams
      Powder (510 Cal)
      Minerals
      Calcium, mg 78 53 400
      Phosphorus, mg 43 29 220
      Magnesium, mg 8 5.4 41
      Iron, mg 1.8 1.22 9.2
      Zinc, mg 1 0.68 5.1
      Manganese, mcg 15 10.1 77
      Copper, mcg 75 51 380
      Iodine, mcg 15 10.1 77
      Selenium, mcg 2.8 1.89 14.3
      Sodium, mg 27 18.3 138
      Potassium, mg 108 73 550
      Chloride, mg 63 43 320
  • Nutrient Facts
    • Nutrient Density 20 Calories/fl oz
      Protein (% Calories) 8.5
      Whey:Casein Ratio 80:20
      Fat (% Calories) 48
      Carbohydrate (% Calories) 43.5
      Potential Renal Solute Load (mOsm/100 Calories)9 19.1
      Potential Renal Solute Load (mOsm/100 mL)9 12.9
      Osmolality (mOsm/kg water) 300
      Osmolarity (mOsm/L) 270
      Lactose-free No
      Galactose-free No
  • Product Forms
    • Enfamil PREMIUM® Newborn is available in powder and ready-to-use liquid.

    • Item #: 165709
      Description: Enfamil PREMIUM Newborn Nursette® 20 Cal RTU
      Unit Size: 2 fl oz bottles
      Cal./Unit:
      Prod. Yield / Unit (fl oz):
      Case: 6 bottles per carton / 4 cartons per case
      Reimbursement Code: 00087165741

    • Item #: 161003
      Description: Enfamil PREMIUM Newborn Pwd
      Unit Size: 22.2 oz tub
      Cal./Unit:
      Prod. Yield / Unit (fl oz):
      Case: 4 tubs per case
      Reimbursement Code: 00087146645

    • Item #: 161005
      Description: Enfamil PREMIUM Newborn Pwd
      Unit Size: 33.2 oz refill box
      Cal./Unit:
      Prod. Yield / Unit (fl oz):
      Case: 4 boxes per case
      Reimbursement Code: 00087510042

  • Composition
    • Ingredients: Powder: Nonfat milk, lactose, vegetable oil (palm olein, coconut, soy and high oleic sunflower oils), whey protein concentrate and less than 2%: galactooligosaccharides#, polydextrose#, Mortierella alpina oil**, Crypthecodinium cohnii oil††, calcium carbonate, calcium phosphate, potassium citrate, magnesium oxide, ferrous sulfate, potassium chloride, zinc sulfate, sodium chloride, cupric sulfate, manganese sulfate, sodium selenite, potassium iodide, soy lecithin, vitamin A palmitate, inositol, choline chloride, ascorbic acid, niacinamide, calcium pantothenate, riboflavin, thiamin hydrochloride, vitamin D3, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, vitamin E acetate, nucleotides (cytidine 5’-monophosphate, disodium uridine 5’-monophosphate, adenosine 5’-monophosphate, disodium guanosine 5’-monophosphate), taurine, L-carnitine.

      Ingredients: Ready To Use (2 fl oz Nursette® bottle): Water, nonfat milk, lactose, vegetable oil (palm olein, soy, coconut and high oleic sunflower oils) and less than 2%: galactooligosaccharides#, polydextrose#, Mortierella alpina oil**, Crypthecodinium cohnii oil††, whey protein concentrate, potassium citrate, calcium phosphate, sodium chloride, calcium chloride, magnesium phosphate, calcium carbonate, ferrous sulfate, sodium citrate, zinc sulfate, cupric sulfate, potassium iodide, manganese sulfate, sodium selenite, mono- and diglycerides, ascorbic acid, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, riboflavin, thiamin hydrochloride, vitamin B6 hydrochloride, folic acid, vitamin K1, vitamin D3, biotin, vitamin B12, soy lecithin, choline chloride, carrageenan, inositol, nucleotides (cytidine 5’-monophosphate, disodium uridine 5’-monophosphate, adenosine 5’-monophosphate, disodium guanosine 5’-monophosphate), taurine, L-carnitine.

      # A type of prebiotic.
      ** A source of arachidonic acid (ARA).
      †† A source of docosahexaenoic acid (DHA).

  • Potential Allergens
    • Enfamil PREMIUM® Newborn contains milk and soy.

  • References
    • 1. Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412.

      2.Kunz C, Lönnerdal B. Re-evaluation of the whey protein/casein ratio of human milk. Acta Paediatr. 1992;81:107-112.

      3. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464.

      4. Birch EE, Khoury JC, Berseth CL, et al. The impact of early nutrition on incidence of allergic manifestations and common respiratory illnesses in children. J Pediatr. 2010;156:902-906.

      5. Scalabrin D, Mitmesser SH, Welling GW, et al. New prebiotic blend of polydextrose and galacto-oligosaccharides has a bifidogenic effect in young infants. J Pediatr Gastroenterol Nutr. 2012;54:343-352.

      6. Salminen S, Endo A, Isolauri E, et al. Early gut colonization with lactobacilli and staphylococcus in infants: the hygiene hypothesis extended. J Pediatr Gastroenterol Nutr. 2016;62:80-86.

      7. Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr. 2007; 44:359-364.

      8. Data on file.

      9. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14.

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