• Phenyl-Free® 2HP - High protein medical food powder for children and adults with phenylketonuria (PKU).

Phenyl-Free® 2HP

High protein medical food powder for children and adults with phenylketonuria (PKU).

Last Updated: Monday, October 5, 2015

  • Indication
    • Phenyl-Free 2 HP is a high protein medical food powder that is free of the essential amino acid phenylalanine for children and adults with phenylketonuria (PKU). It provides all other essential amino acids as well as nonessential amino acids, carbohydrate, fat, essential fatty acids, vitamins and minerals. Phenyl-Free 2 HP is appropriate for women with maternal PKU or for children and adults who require fewer calories than provided by Phenyl-Free® 2. Use under direct and continuing supervision of a doctor.

  • Product Features
      • Phenylalanine-free

      • 40 g protein equivalents/100 g powder

      • Higher level of protein equivalents than found in Phenyl‑Free 2

      • Suitable for someone with lactose intolerance

      • Vanilla scent

      • Can be easily modified with preferred flavor enhancers

      • Mixes easily and stays in suspension well

      • Higher levels of most vitamins and minerals than found in Phenyl-Free 2

      (Note: Due to the higher levels of amino acids in Phenyl-Free 2 HP, the taste of amino acids is more prevalent in this product than it is in Phenyl-Free 2.)

  • Nutrients*
    • Per 100 grams Powder
      Calories 390
      Protein equivalent, g 40
      Fat, g 6.3
      Linoleic acid, mg 3000
      Linolenic acid, mg 380
      Carbohydrate, g 44
      Per 100 grams Powder
      Vitamins ⁄ Other Nutrients
      Vitamin A, IU 2000
      Vitamin D, IU 390
      Vitamin E, IU 11.8
      Vitamin K, mcg 51
      Thiamin (Vitamin B1), mcg 1570
      Riboflavin (Vitamin B2), mcg 1290
      Vitamin B6, mcg 1290
      Vitamin B12, mcg 3.1
      Niacin, mcg 29000
      Folic acid (Folacin), mcg 470
      Pantothenic acid, mcg 6300
      Biotin, mcg 63
      Vitamin C (Ascorbic acid), mg 63
      Choline, mg 67
      Inositol, mg 63
      Taurine, mg 63
      Carnitine, mg 36
      Per 100 grams Powder
      Calcium, mg 980
      Phosphorus, mg 980
      Magnesium, mg 290
      Iron, mg 15.7
      Zinc, mg 15.7
      Manganese, mcg 1570
      Copper, mcg 1570
      Iodine, mcg 50
      Selenium, mcg 36
      Sodium, mg 410
      Potassium, mg 1180
      Chloride, mg 980
      Molybdenum, mcg 51
      Chromium, mcg 51

      * Product nutrient values and ingredients are subject to change. Please see product label for current information.

      † Protein is incomplete since it does not contain the essential amino acid phenylalanine.

  • Nutrient Facts
    • Protein Equivalent (% Calories) 41
      Fat (% Calories) 15
      Carbohydrate (% Calories) 44
      Lactose-Free Yes
      Galactose-Free Yes

      † Protein is incomplete since it does not contain the essential amino acid phenylalanine.

  • Product Form
    • Phenyl-Free® 2 HP is available in powder.

      Item #: 891401
      Description: Powder
      Unit Size: 1 lb can
      Cal./Unit: 1770
      Prod. Yield / Unit (fl oz): Varies
      Case: 6 cans per case
      HCPCS Code: B4157 or B4162
      Reimbursement Code: 00087-510010 N/A

      HCPCS Code

  • Composition
    • Ingredients: Amino acids (L-glutamine, L-leucine, potassium aspartate, L-lysine hydrochloride, L-tyrosine, L-proline, L-valine, L-isoleucine, L-alanine, L-arginine, L-threonine, L-serine, glycine, L-histidine, L-methionine, L-tryptophan, L-cystine), sugar, corn syrup solids, soy oil, modified corn starch, calcium phosphate, magnesium phosphate, and less than 1%: sodium citrate, potassium chloride, sodium phosphate, potassium citrate, choline chloride, ascorbic acid, taurine, inositol, ferrous sulfate, zinc sulfate, niacinamide, L-carnitine, vitamin E acetate, vitamin A palmitate, calcium pantothenate, cupric sulfate, manganese sulfate, vitamin B12, thiamin hydrochloride, vitamin B6 hydrochloride, riboflavin, folic acid, vitamin D3, chromic chloride, sodium molybdate, sodium selenite, biotin, vitamin K1, sodium iodide, ethyl vanillin.

  • Preparation of Feedings
    • Metabolic clinician should consult with patients about the correct amounts of water and powder for consumption. The patient's health depends on carefully following these directions.

      Measure the correct amount of water into a suitable container for mixing. Then add the required amount of Phenyl-Free 2 HP. Mix well until blended. Consume the prepared beverage immediately or cover and refrigerate. Use within 48 hours of preparation. Mix before drinking.

      Throw away prepared unrefrigerated beverage left in cup within 1 hour after consumption begins.

      Powder Storage (cans)

      Store cans at room temperature. After opening can, keep tightly covered, store in a dry area and use contents within 1 month. Do not freeze powder, and avoid excessive heat. Use by date on bottom of can.


      An unpacked level scoop delivers approximately 15.1 g of powder. Store the DRY scoop in this can.


      This product is nutritionally incomplete. Continuing medical supervision and frequent blood tests are required. Care must be taken to provide enough phenylalanine to support growth, using other foods with this amino acid as required.

      Nutritional powders are not sterile.

      WARNING: Not for parenteral (I.V.) use.

  • Product Characteristics
    • Fat

      Fat provides 15% of total calories in Phenyl-Free® 2 HP. The fat source is soy oil. Soy oil is a source of the essential omega-6 and omega-3 fatty acids: linoleic acid and alpha-linolenic acid.


      Protein equivalents provide 41% of total calories in Phenyl-Free 2 HP. The product provides the essential amino acids (except phenylalanine) as well as nonessential amino acids (see Amino Acids table). Care must be taken to provide enough phenylalanine from other foods to support growth and tissue maintenance. The level of protein equivalents in Phenyl-Free 2 HP is almost 2 times higher than those found in Phenyl-Free 2. The higher protein equivalent concentration in Phenyl-Free 2 HP helps children and adults with PKU meet their protein needs while consuming fewer calories from the product. This, in turn, allows Phenyl-Free 2 HP users to consume a greater variety of foods in order to meet their phenylalanine and calorie needs. The product is appropriate for women with maternal PKU and children and adults who require fewer calories than provided by Phenyl-Free 2.

      Amino Acids

      Essential Amino Acids Per 100 g Powder
      Histidine, mg 1000
      Isoleucine, mg 2800
      Leucine, mg 5200
      Lysine, mg 3200
      Methionine, mg 880
      Cystine, mg 600
      Phenylalanine, mg 0
      Tyrosine, mg 4000
      Threonine, mg 1840
      Tryptophan, mg 720
      Valine, mg 3100
      Nonessential Amino Acids Per 100 g Powder
      Arginine, mg 2400
      Alanine, mg 2600
      Aspartic acid, mg 3200
      Glutamic acid, mg 6300
      Glycine, mg 1440
      Proline, mg 3200
      Serine, mg 1560

      ‡ Added as glutamine.


      Carbohydrate provides 44% of total calories in Phenyl-Free 2 HP. The carbohydrate blend is sucrose (table sugar), corn syrup solids, carbohydrate from the amino acid premix and modified corn starch. The sucrose in the product helps mask the taste of the amino acids. Phenyl-Free 2 HP is suitable for someone with lactose intolerance.

      Vitamins and Minerals

      Phenyl-Free 2 HP provides essential vitamins and minerals at levels that are appropriate for children and adults. The levels of most vitamins and minerals in Phenyl-Free 2 HP are higher than levels found in Phenyl-Free 2.