• Description/Indication
    • OA 1 is an iron-fortified infant formula and medical food powder that is free of the essential amino acids isoleucine, methionine, threonine and valine for infants and toddlers with documented propionic or methylmalonic acidemia (organic acidemias). The product provides the other essential amino acids as well as nonessential amino acids, carbohydrate, fat, essential fatty acids, vitamins and minerals. Use under direct and continuing supervision of a doctor.

  • Product Features
      • DHA and ARA
      • Isoleucine-, methionine-, threonine- and valine-free
      • Vitamin and mineral levels meet the U.S. Infant Formula Act requirements per 100 Calories
      • Increased levels of B vitamins, compared to routine infant formulas, for cofactor production
      • Vanilla scent
      • Mixes easily and stays in suspension well
      • Has choline, an essential nutrient important for brain development and the normal functioning of cells1,2
      • Halal
  • Nutrients
    • Product nutrient values and ingredients are subject to change. Please see product label for current information.

      Per 100 grams Powder
      Calories 500
      Protein equivalent, g* 15.7
      Fat, g 26
      Linoleic acid, mg 4000
      Carbohydrate, g 51
      Per 100 grams Powder
      Vitamins/Other Nutrients
      Vitamin A, IU 1520
      Vitamin D, IU 380
      Vitamin E, IU 10
      Vitamin K, mcg 40
      Thiamin (Vitamin B1), mcg 1000
      Riboflavin (Vitamin B2), mcg 1000
      Vitamin B6, mcg 1000
      Vitamin B12, mcg 2
      Niacin, mcg 10000
      Folic acid (Folacin), mcg 100
      Pantothenic acid, mcg 3800
      Biotin, mcg 38
      Vitamin C (Ascorbic acid), mg 60
      Choline, mg 124
      Inositol, mg 86
      Per 100 grams Powder
      Calcium, mg 660
      Phosphorus, mg 440
      Magnesium, mg 66
      Iron, mg 9.6
      Zinc, mg 8.6
      Manganese, mcg 380
      Copper, mcg 860
      Iodine, mcg 76
      Selenium, mcg 14.1
      Sodium, mg 240
      Potassium, mg 560
      Chloride, mg 480

      * WARNING: Protein is incomplete since it does not contain the essential amino acids isoleucine, methionine, threonine and valine.

  • Nutrient Facts
    • Protein Equivalent (% Calories)* 12
      Fat (% Calories) 47
      Carbohydrate (% Calories) 41
      Potential Renal Solute Load (mOsm/100 g powder)3 142
      Osmolality (mOsm/kg water) 370
      Osmolarity (mOsm/L) 330
      Lactose-Free Suitable for someone with lactose intolerance

      * WARNING: Protein is incomplete since it does not contain the essential amino acids isoleucine, methionine, threonine and valine. † Determined at 20 Cal/fl oz dilution.

  • Product Form
    • OA 1 is available in powder.

      Item #: 893201
      Description: Powder
      Unit Size: 1 lb can
      Cal./Unit: 2280
      Prod. Yield / Unit (fl oz): Varies
      Case: 6 cans per case
      HCPCS Code: B4162
      Reimbursement Code: 00087-510199

      HCPCS Code

  • Composition
    • Ingredients: Corn syrup solids, vegetable oil (palm olein oil, coconut oil, soy oil, high oleic sunflower oil), amino acids (L-alanine, L-leucine, L-lysine hydrochloride, potassium aspartate, L-proline, L-arginine, glycine, L-phenylalanine, L-tyrosine, L-serine, L-histidine, L-tryptophan, L-cystine), modified corn starch, sugar, calcium phosphate and less than 1%: Mortierella alpina oil, Crypthecodinium cohnii oil§, ethyl vanillin, sodium citrate, potassium citrate, magnesium oxide, ferrous sulfate, potassium chloride, zinc sulfate, cupric sulfate, manganese sulfate, sodium iodide, sodium selenite, choline chloride, inositol, ascorbic acid, niacinamide, calcium pantothenate, vitamin B6 hydrochloride, thiamin hydrochloride, riboflavin, vitamin D3, folic acid, biotin, vitamin K1, vitamin E acetate, vitamin A palmitate, vitamin B12, taurine, L-carnitine.

      ‡ A source of arachidonic acid (ARA). § A source of docosahexaenoic acid (DHA).

      CAUTION: Mead Johnson Nutrition OA 1 is to be used only in the dietary management of infants and young children with documented propionic and methylmalonic acidemias while under direct and continuing medical supervision.

      WARNING: This product is nutritionally incomplete. Care must be taken to provide enough isoleucine, methionine, threonine and valine to support growth using other foods with these amino acids as required. Medical professionals must carefully and constantly supervise use of OA 1 with other foods and liquids and adjust the diet based on frequent blood tests.

      WARNING: Not for parenteral (I.V.) use.

  • Preparation of Feedings
    • The baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Powdered infant formulas are not sterile and should not be fed to premature infants or infants who might have immune problems unless directed and supervised by a doctor. Discuss with parents which formula is appropriate for the baby.

      Discuss with parents whether they need to use cooled, boiled water for mixing and whether they need to boil clean utensils, bottles and nipples in water before use.

      WARNING: Do not use a microwave oven to warm formula. Serious burns may result.

      Refer to the product label for the most accurate information.

      The baby’s medical professional will provide instructions for the correct amounts of water and powder. Pour the required amount of water into the bottle. Add the correct amount of powder, cap the bottle and shake vigorously.

      If instructed to use the scoop in the can, each unpacked, level scoop delivers approximately 4.5 g of powder. Store DRY scoop in can.

  • Product Characteristics
    • Fat

      Fat provides 47% of total calories in OA 1. The fat content is similar to the fat content of human milk and consists of a four-oil vegetable blend of palm olein oil (44%), soy oil (19.5%), coconut oil (19.5%), and high oleic sunflower oil (14.5%) along with ARA and DHA from single cell oils (2.5%). This fat blend provides a fatty acid profile similar to the fatty acid profile of breast milk.

      ¶ Comparisons based on fatty acid profile of typical mature U.S. breast milk.


      Protein equivalents provide 12% of total calories in OA 1. Since the product contains no isoleucine, methionine, threonine, and valine, care must be taken to provide enough isoleucine, methionine, threonine, and valine from breast milk, infant formula, or other foods to support growth.

      Amino Acids

      Essential Amino Acids Per 100 g Powder
      Histidine, mg 470
      Isoleucine, mg 0
      Leucine, mg 2400
      Lysine, mg 1510
      Methionine, mg 0
      Cystine, mg 290
      Phenylalanine, mg 790
      Tyrosine, mg 790
      Threonine, mg 0
      Tryptophan, mg 350
      Valine, mg 0
      Nonessential Amino Acids Per 100 g Powder
      Arginine, mg 1000
      Alanine, mg 4600
      Aspartic acid, mg 1320
      Glutamic acid, mg 0
      Glycine, mg 1000
      Proline, mg 1320
      Serine, mg 690


      Carbohydrate provides 41% of total calories in OA 1. The carbohydrate blend is corn syrup solids, modified corn starch, and sucrose (table sugar). The sucrose in the product helps neutralize the taste of the amino acids. OA 1 is Suitable for someone with lactose intolerance.

      Vitamins and Minerals

      Vitamin and mineral levels in OA 1 meet U.S. Food and Drug Administration requirements per 100 Calories for vitamins and minerals as mandated by the U.S. Infant Formula Act and the associated Code of Federal Regulations 21 C.F.R. part 107.1004. Amounts of B vitamins have been increased above levels in routine infant formulas for cofactor production. Increased level of choline, an essential nutrient important for brain development and the normal functioning of cells1-2. Calcium, iron, zinc, manganese, and copper levels are higher in order to help meet the needs for these minerals when low-protein solid foods are introduced.

  • References
    • 1. Food and Nutrition Board, Institute of Medicine, Choline. In: Dietary References Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press; 1998:390-422.

      2. Zeisel SH, da Costa KA. Nutr Rev. 2009;67(11):615–623.

      3. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11–14.

      4. Nutrient Requirements for Infant Formulas. Code of Federal Regulations 21, C.F.R. 107.100.