Enfamil® ProSobee®

Soy for Sensitive Tummy. Soy-based infant formula for the first 12 months.

Last Updated: Thursday, December 7, 2017 - 19:00

ProSobee was shown to help infants in just 24 hours

Description/Indication

Enfamil ProSobee is a 20 Cal/fl oz soy-based formula for the routine feeding of infants with feeding issues resulting from sensitivity to milk-based formula. Enfamil ProSobee is for babies with sensitive tummies when a soy formula is preferred. Enfamil ProSobee is lactose-free.

Long-Term Usage: Enfamil ProSobee is designed to provide a sole source of nutrition for infants up to age 6 months, and provide a major source of nutrition through 12 months of age when indicated.

Product Features:

  • DHA at the clinically proven* amount of 0.32% of total fatty acids, the same amount as the worldwide breast amilk average1,†, and double the amount found in the leading competitors product:
    • Clinically shown to improve long-term cognitive outcomes through 5 years of age2 vs. prior Enfamil® without DHA
  • Clinically proven to reduce fussiness and gas in 24 hours3,§
  • Plant-sourced protein
  • Milk-free and suitable for infants with lactose intolerance
  • Dairy-free for when parents want to avoid cow’s milk in their baby’s diet
  • No artificial flavors, sweeteners or colors
  • Lactose-free
  • Kosher (Pareve ingredients; manufactured on dairy equipment)


* Studies compared infants fed Enfamil with DHA and ARA vs. discontinued Enfamil without DHA and ARA; studied before the addition of prebiotics.

† Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women1.

‡ Enfamil ProSobee has not been shown superior to the leading competitor in supporting mental, visual and immune system development. The level of DHA in Similac Pro-Advance is ~0.15% of total fatty acids.

  • Nutrients
    • (Normal Dilution)

      Per 100 Cal (5 fl oz) Powder

      Per 100 Cal (5 fl oz) 2 fl oz RTU

      Per 100 Cal (5 fl oz) 8 fl oz RTU

      Per 100 Cal (5 fl oz) 13 fl oz Conc

      Per 100 mL Powder

      Per 100 mL 2 fl oz RTU

      Per 100 mL 8 fl oz RTU

      Per 100 mL 13 fl oz Conc

      Per 100 grams Powder (510 Cal)

      Protein, g

      2.5

      2.5

      2.5

      2.5

      1.69

      1.69

      1.69

      1.69

      12.7

      Fat, g

      5.3

      5.3

      5.3

      5.3

      3.6

      3.6

      3.6

      3.6

      27

      Linoleic acid, mg

      800

      860

      860

      860

      540

      580

      580

      580

      4100

      Carbohydrate, g

      10.6

      10.6

      10.6

      10.6

      7.2

      7.2

      7.2

      7.2

      54

      Water, g

      133

      133

      134

      134

      90

      90

      91

      91

      2.6

      Vitamins/Other Nutrients

      Vitamin A, IU

      300

      300

      300

      300

      200

      200

      200

      200

      1530

      Vitamin D, IU

      60

      60

      60

      60

      41

      41

      41

      41

      310

      Vitamin E, IU

      2

      2

      2

      2

      1.35

      1.35

      1.35

      1.35

      10.2

      Vitamin K, mcg

      9

      9

      9

      9

      6.1

      6.1

      6.1

      6.1

      46

      Thiamin (Vitamin B1), mcg

      80

      80

      80

      80

      54

      54

      54

      54

      410

      Riboflavin (Vitamin B2), mcg

      90

      90

      90

      90

      61

      61

      61

      61

      460

      Vitamin B6, mcg

      60

      60

      60

      60

      41

      41

      41

      41

      310

      Vitamin B12, mcg

      0.3

      0.3

      0.3

      0.3

      0.2

      0.2

      0.2

      0.2

      1.53

      Niacin, mcg

      1000

      1000

      1000

      1000

      680

      680

      680

      680

      5100

      Folic acid (Folacin), mcg

      16

      16

      16

      16

      10.8

      10.8

      10.8

      10.8

      81

      Pantothenic acid, mcg

      500

      500

      500

      500

      340

      340

      340

      340

      2500

      Biotin, mcg

      3

      3

      3

      3

      2

      2

      2

      2

      15.3

      Vitamin C (Ascorbic acid), mg

      12

      12

      12

      12

      8.1

      8.1

      8.1

      8.1

      61

      Choline, mg

      24

      24

      24

      24

      16.2

      16.2

      16.2

      16.2

      122

      Inositol, mg

      6

      6

      6

      6

      4.1

      4.1

      4.1

      4.1

      31

      Minerals

      Calcium, mg

      105

      105

      105

      105

      71

      71

      71

      71

      530

      Phosphorus, mg

      69

      69

      69

      69

      47

      47

      47

      47

      350

      Magnesium, mg

      8

      8

      8

      8

      5.4

      5.4

      5.4

      5.4

      41

      Iron, mg

      1.8

      1.8

      1.8

      1.8

      1.22

      1.22

      1.22

      1.22

      9.2

      Zinc, mg

      1.2

      1.2

      1.2

      1.2

      0.81

      0.81

      0.81

      0.81

      6.1

      Manganese, mcg

      25

      25

      25

      25

      16.9

      16.9

      16.9

      16.9

      127

      Copper, mcg

      75

      75

      75

      75

      51

      51

      51

      51

      380

      Iodine, mcg

      15

      15

      15

      15

      10.1

      10.1

      10.1

      10.1

      76

      Selenium, mcg

      2.8

      2.8

      2.8

      2.8

      1.89

      1.89

      1.89

      1.89

      14.2

      Sodium, mg

      36

      36

      36

      36

      24

      24

      24

      24

      183

      Potassium, mg

      120

      120

      120

      120

      81

      81

      81

      81

      610

      Chloride, mg

      80

      80

      80

      80

      54

      54

      54

      54

      410

      Product nutrient values and ingredients are subject to change. Please see product label for current information.

  • Nutrient Facts
    • Nutrient Density20 Calories/fl oz
      Protein (% Calories)10
      Fat (% Calories)48
      Carbohydrate (% Calories)42
      Potential Renal Solute Load (mOsm/100 Calories)<sup>4</sup>23
      Potential Renal Solute Load (mOsm/100 mL)<sup>4</sup>15.6
      Osmolality (mOsm/kg water)200 (2 fl oz) 178 (Pwd) 170 (8 fl oz RTU, 13 fl oz Conc)
      Osmolarity (mOsm/L)180 (2 fl oz) 160 (Pwd) 155 (8 fl oz RTU, 13 fl oz Conc)
      Lactose-freeYes
  • Availability

      Enfamil® ProSobee® is available in powder, ready-to-use liquid and concentrate.

      When using this information, please note the following:

      Coding systems and reimbursement allowable rates vary by payer:

      • Medicare Part B uses HCPCS (Healthcare Common Procedure Coding System) to group products
      • Medicaid systems vary by state; some use HCPCS while others use NDC format code or systems of their own—contact your state provider for more information
      • Private health insurance and managed care companies may use HCPCS, NDC format code or their own system—contact your provider for more information


    • Product: Enfamil® ProSobee®
      Item #: 119501
      Description: Concentrate
      Unit Size: 13 fl oz can
      Calories/Unit: 520
      Product Yield/Unit (fl oz): 26
      Case: 12 cans per case
      HCPCS Code: B4159
      NDC Format Code: 00087-1195-41
    • Product: Enfamil ProSobee
      Item #: 121401
      Description: Powder
      Unit Size: 12.9 oz can
      Calories/Unit: 1860
      Product Yield/Unit (fl oz): 93
      Case: 6 cans per case
      HCPCS Code: B4159
      NDC Format Code: 00087-1214-41
    • Product: Enfamil ProSobee
      Item #: 121460
      Description: Powder
      Unit Size: 22 oz can
      Calories/Unit: 3180
      Product Yield/Unit (fl oz): 159
      Case: 4 cans per case
      HCPCS Code: B4159
      NDC Format Code: 00087-1214-42
    • Product: Enfamil ProSobee
      Item #: 144901
      Description: RTU
      Unit Size: 2 fl oz bottle
      Calories/Unit: 40
      Product Yield/Unit (fl oz): 2
      Case: 48 bottles per case
      HCPCS Code: B4159
      NDC Format Code: 00087-1449-41
    • Product: Enfamil ProSobee
      Item #: 149801
      Description: RTU
      Unit Size: 8 fl oz bottle
      Calories/Unit: 160
      Product Yield/Unit (fl oz): 8
      Case: 24 bottles per case
      HCPCS Code: B4159
      NDC Format Code: 00087-5102-50
  • Composition
    • Ingredients: Powder: Corn syrup solids (54%), vegetable oil (26%) (palm olein, coconut, soy and high oleic sunflower oils), soy protein isolate (14%) and less than 2%: calcium phosphate, potassium chloride, sodium citrate, calcium carbonate, magnesium chloride, magnesium phosphate, potassium citrate, ferrous sulfate, zinc sulfate, cupric sulfate, potassium iodide, sodium selenite, Mortierella alpina oil§, Crypthecodinium cohnii oil||, L-methionine, choline chloride, ascorbic acid, niacinamide, calcium pantothenate, vitamin D3, riboflavin, thiamin hydrochloride, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, inositol, taurine, vitamin E acetate, L-carnitine, vitamin A palmitate.

      Ingredients: Ready To Use (2 fl oz Nursette® bottle): Water (87%), corn syrup solids (7%), vegetable oil (palm olein, soy, coconut and high oleic sunflower oils) (3%), soy protein isolate (2%) and less than 1%: Mortierella alpina oil, Crypthecodinium cohnii oil§, calcium phosphate, potassium citrate, calcium carbonate, sodium chloride, magnesium chloride, magnesium phosphate, potassium chloride, ferrous sulfate, zinc sulfate, cupric sulfate, potassium iodide, sodium selenite, soy lecithin, ascorbic acid, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, vitamin B12, vitamin D3, thiamin hydrochloride, riboflavin, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, mono- and diglycerides, L-methionine, choline chloride, carrageenan, inositol, taurine, L-carnitine.

      Ingredients: Ready To Use (8 fl oz bottle): Water (87%), corn syrup solids (7%), vegetable oil (palm olein, soy, coconut and high oleic sunflower oils) (3%), soy protein isolate (2%) and less than 1%: Mortierella alpina oil, Crypthecodinium cohnii oil§, calcium phosphate, potassium citrate, sodium chloride, calcium carbonate, potassium chloride, magnesium phosphate, magnesium chloride, ferrous sulfate, zinc sulfate, cupric sulfate, potassium iodide, sodium selenite, soy lecithin, mono- and diglycerides, L-methionine, carrageenan, choline chloride, ascorbic acid, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, thiamin hydrochloride, riboflavin, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, inositol, vitamin B12, vitamin D3, taurine, L-carnitine.

      Ingredients: Concentrate (13 fl oz can): Water (75%), corn syrup solids (14%), vegetable oil (palm olein, soy, coconut and high oleic sunflower oils) (6%), soy protein isolate (4%) and less than 1%: Mortierella alpina oil, Crypthecodinium cohnii oil§, mono- and diglycerides, soy lecithin, carrageenan, vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, thiamin hydrochloride, riboflavin, vitamin B6 hydrochloride, vitamin B12, niacinamide, folic acid, calcium pantothenate, biotin, ascorbic acid, choline chloride, inositol, calcium carbonate, calcium phosphate, magnesium chloride, magnesium phosphate, ferrous sulfate, zinc sulfate, cupric sulfate, potassium iodide, sodium selenite, sodium chloride, potassium citrate, potassium chloride, L-methionine, taurine, L-carnitine.

      § A source of arachidonic acid (ARA).

      || A source of docosahexaenoic acid (DHA).

  • Potential Allergens
    • Enfamil® ProSobee® contains soy.

  • Amino Acid Composition
    • ESSENTIAL AMINO ACIDS
      mg/100 Calmg/100 g Pwd
      Histidine65330
      Isoleucine115580
      Leucine2001000
      Lysine158800
      Methionine63320
      Cysteine31156
      Phenylalanine133670
      Tyrosine95480
      Threonine98500
      Tryptophan37185
      Valine118600
      NONESSENTIAL AMINO ACIDS
      mg/100 Calmg/100 g Pwd
      Arginine185940
      Alanine108550
      Aspartic Acid2901460
      Glutamic Acid4702400
      Glycine103520
      Proline123620
      Serine128650
      Tyrosine95480
      Threonine98500
      Tryptophan37185
      Valine118600

      ‡ Methionine level is 53 mg/100 Cal in 13 fl oz concentrate.

  • Preparation of Feedings
    • Powder

      The baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Powdered infant formulas are not sterile and should NOT be fed to premature infants or infants who might have immune problems unless directed and supervised by a doctor. Discuss with parents which formula is appropriate for the baby.

      Discuss with parents whether they need to use cooled, boiled water for mixing and whether they need to boil clean utensils, bottles and nipples in water before use.

      WARNING: Do not use a microwave oven to warm formula. Serious burns may result.

      Refer to the product label for the most accurate information.

      Failure to follow these instructions could result in severe harm.Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use formula within 1 hour or discard.

      1. Wash hands thoroughly with soap and water before preparing formula.
      2. Pour the desired amount of water into the bottle. Add powder.
      3. Cap bottle and SHAKE WELL.


      Use the following chart for correct amounts of water and powder. Use scoop in tub or can to measure powder. Store DRY scoop in lid holder in tub or in can.

      Enfamil ProSobee
      To Make<sup>*</sup>WaterPowder Weight
      2 fl oz bottle2 fl oz1 unpacked level scoop8.8 g
      4 fl oz bottle4 fl oz2 unpacked level scoops17.6 g
      8 fl oz bottle8 fl oz4 unpacked level scoops35.2 g
    • Ready-to-Use

      The baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Discuss with parents which formula is appropriate for the baby.

      8 fl oz Bottles

      1. Wash hands thoroughly with soap and water before preparing feeding bottles.
      2. SHAKE BOTTLE WELL, remove protective seal around cap, remove cap and foil seal.
      3. Pour into feeding bottle(s).


      WARNING: Do not use a microwave oven to warm formula. Serious burns may
      result.

      Failure to follow these instructions could result in severe harm. Opened bottles and prepared formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 48 hours. Do not use opened bottle and/or prepared formula if they are unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use prepared formula within 1 hour or discard.

    • Concentrate

      The baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Discuss with parents which formula is appropriate for the baby.

      13 fl oz Cans

      1. Wash hands thoroughly with soap and water before preparing formula.
      2. Clean can lid, SHAKE CAN WELL and open.
      3. Pour desired amount of water into the bottle. Add an equal amount of concentrated liquid. Shake or stir well.


      WARNING: Do not use a microwave oven to warm formula. Serious burns may
      result.



      Failure to follow these instructions could result in severe harm. Opened bottles or cans and prepared formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 48 hours. Do not use opened containers and/or prepared formula if they are unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use prepared formula within 1 hour or discard.

  • References
      1. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464.
      2. Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412.
      3. Berseth CL, Johnston WH, Stolz SI, et al. Clinical response to 2 commonly used switch formulas occurs within 1 day. Clin Pediatr (Phila). 2009;48:58-65.
      4. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14.
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