Enfamil® Gentlease®

For fussiness, gas and crying. Milk-based infant formula that has partially broken down proteins for the first 12 months.

Last Updated: Monday, January 8, 2018 - 19:00

#1 Pediatrician recommended brand for gassy and fussy babies*

Description/Indication

Enfamil Gentlease is a 20 Cal/fl oz, milk-based infant formula designed to reduce fussiness, gas and crying1. It has an easy-to-digest milk protein blend patterned after breast milk (whey and casein in a 60:40 ratio)* that has been partially broken down. The formula is nutritionally balanced and has docosahexaenoic acid (DHA) and arachidonic acid (ARA), nutrients also found in breast milk that promote brain and eye development.

Long-Term Usage: Enfamil Gentlease is designed to provide the sole source of nutrition for infants up to age 6 months and provide a major source of nutrition for the remainder of the first year.

* Comparison to whey-to-casein ratio of typical mature breast milk (15 days to 6 months after birth) prior to hydrolysis.

Product Features:

  • DHA at the clinically proven amount of 0.32% of total fatty acids, the same amount as the worldwide breast milk average2,‡, and double the
    amount found in the leading competitor’s product§:

    • Clinically proven to support mental, visual and immune system development
    • Clinically shown to improve long-term cognitive outcomes through 5 years of age3
    • Shown to improve respiratory health through the first 3 years of life when infants were fed through 12 months4,†
  • Designed to reduce fussiness, gas and crying in 24 hours1
  • A special blend of easy-to-digest proteins, patterned after the blend of proteins found in breast milk*, that have been partially broken down
  • Has ~20% of lactose|| as a source of carbohydrates; infants with transient lactase deficiency generally can tolerate formulas with some lactose
  • No artificial flavors, sweeteners or colors
  • Kosher


* Comparison to whey-to-casein ratio of typical mature breast milk (15 days to 6 months after birth) prior to hydrolysis.

† Studies compared infants fed Enfamil® with DHA and ARA vs. discontinued Enfamil without DHA and ARA; studied before the addition of prebiotics.

‡ Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women2.

§ Enfamil Gentlease has not been shown superior to the leading competitor in supporting mental, visual and immune system development. The level of DHA in Similac Pro-Advance is ~0.15% of total fatty acids.

  • Nutrients
    • (Normal Dilution)

      Per 100 Calories (5 fl oz) Powder

      Per 100 Calories (5 fl oz) 2 fl oz

      Per 100 Calories (5 fl oz) 6 fl oz

      Per 100 Calories (5 fl oz) 8 fl oz

      Per 100 mL Powder

      Per 100 mL 2 fl oz

      Per 100 mL 6 fl oz

      Per 100 mL 8 fl oz

      Per 100 grams Powder (510 Cal)

      Protein, g

      2.3

      2.3

      2.3

      2.3

      1.56

      1.55

      1.55

      1.56

      11.7

      Fat, g

      5.3

      5.3

      5.3

      5.3

      3.6

      3.6

      3.6

      3.6

      27

      Linoleic acid, mg

      800

      860

      800

      860

      540

      580

      540

      580

      4100

      Carbohydrate, g

      10.8

      10.8

      10.8

      10.8

      7.3

      7.3

      7.3

      7.3

      55

      Water, g

      133

      133

      133

      133

      90

      90

      90

      90

      2.4

      Vitamins/Other Nutrients

      Vitamin A, IU

      300

      300

      300

      300

      200

      200

      200

      200

      1530

      Vitamin D, IU

      60

      60

      60

      60

      41

      41

      41

      41

      310

      Vitamin E, IU

      2

      2

      2

      2

      1.35

      1.35

      1.35

      1.35

      10.2

      Vitamin K, mcg

      9

      9

      9

      9

      6.1

      6.1

      6.1

      6.1

      46

      Thiamin (Vitamin B1,), mcg

      80

      80

      80

      80

      54

      54

      54

      54

      410

      Riboflavin (Vitamin B2,), mcg

      140

      140

      140

      140

      95

      95

      95

      95

      710

      Vitamin B6,, mcg

      60

      60

      60

      60

      41

      41

      41

      41

      310

      Vitamin B12, mcg

      0.3

      0.3

      0.3

      0.3

      0.2

      0.2

      0.2

      0.2

      1.53

      Niacin, mcg

      1000

      1000

      1000

      1000

      680

      680

      680

      680

      5100

      Folic acid (Folacin), mcg

      16

      16

      16

      16

      10.8

      10.8

      10.8

      10.8

      82

      Pantothenic acid, mcg

      500

      500

      500

      500

      340

      340

      340

      340

      2600

      Biotin, mcg

      3

      3

      3

      3

      2

      2

      2

      2

      15.3

      Vitamin C (Ascorbic acid), mg

      12

      12

      12

      12

      8.1

      8.1

      8.1

      8.1

      61

      Choline, mg

      24

      24

      24

      24

      16.2

      16.2

      16.2

      16.2

      122Inositol, mg

      6

      6

      6

      6

      4.1

      4.1

      4.1

      4.1

      31

      Minerals

      Calcium, mg

      82

      82

      82

      82

      55

      55

      55

      55

      420

      Phosphorus, mg

      46

      46

      46

      46

      31

      31

      31

      31

      230

      Magnesium, mg

      8

      8

      8

      8

      5.4

      5.4

      5.4

      5.4

      41

      Iron, mg

      1.8

      1.8

      1.8

      1.8

      1.22

      1.22

      1.22

      1.22

      9.2

      Zinc, mg

      1

      1

      1

      1

      0.68

      0.68

      0.68

      0.68

      5.1

      Manganese, mcg

      15

      15

      15

      15

      10.1

      10.1

      10.1

      10.1

      77

      Copper, mcg

      75

      75

      75

      75

      51

      51

      51

      51

      380

      Iodine, mcg

      15

      15

      15

      15

      10.1

      10.1

      10.1

      10.1

      77

      Selenium, mcg

      2.8

      2.8

      2.8

      2.8

      1.89

      1.89

      1.89

      1.89

      14.3

      Sodium, mg

      36

      36

      36

      36

      24

      24

      24

      24

      184

      Potassium, mg

      108

      108

      108

      108

      73

      73

      73

      73

      550

      Chloride, mg

      63

      63

      63

      63

      43

      43

      43

      43

      320

      Product nutrient values and ingredients are subject to change. Please see product label for current information.

  • Nutrient Facts
    • Nutrient Density

      20 Calories/fl oz

      Protein (% Calories)

      9

      Whey:Casein Ratio

      60:40

      Fat (% Calories)

      48

      Carbohydrate (% Calories)

      43

      Potential Renal Solute Load (mOsm/100 Calories)5

      21

      Potential Renal Solute Load (mOsm/100 mL) 5

      14

      Osmolality (mOsm/kg water)

      230 (Pwd), 220 (RTU)

      Osmolarity (mOsm/L)

      210 (Pwd), 200 (RTU)

      Lactose-free

      No

  • Product Forms

      Enfamil Gentlease is available in powder and ready-to-use liquid.

      When using this information, please note the following:

      Coding systems and reimbursement allowable rates vary by payer:

      • Medicare Part B uses HCPCS (Healthcare Common Procedure Coding System) to group products
      • Medicaid systems vary by state; some use HCPCS while others use NDC format code or systems of their own—contact your state provider for more information
      • Private health insurance and managed care companies may use HCPCS, NDC format code or their own system—contact your provider for more information

    • Product: Enfamil® Gentlease®
      Item #: 869318
      Description: Powder
      Unit Size: 29.1 oz can
      Calories/Unit: 4200
      Product Yield/Unit (fl oz): 210
      Case: 4 cans per case
      HCPCS Code: B4158
      NDC Format Code: 00087-5121-25
    • Product: Enfamil Gentlease
      Item #: 8693Y4
      Description: Powder
      Unit Size: 20.9 oz can
      Calories/Unit: 3020
      Product Yield/Unit (fl oz): 151
      Case: 4 cans per case
      HCPCS Code: B4158
      NDC Format Code: 00087-5119-78
    • Product: Enfamil Gentlease
      Item #: 129501
      Description: RTU
      Unit Size: 6 fl oz bottle
      Calories/Unit: 120
      Product Yield/Unit (fl oz): 6
      Case: 24 bottles per case
      HCPCS Code: B4158
      NDC Format Code: 00087-5105-23
  • Composition
    • Ingredients: Powder: Corn syrup solids, partially hydrolyzed nonfat milk and whey protein concentrate solids (soy), vegetable oil (palm olein, soy, coconut and high oleic sunflower oils) and less than 2%: Mortierella alpina oil*, Crypthecodinium cohnii oil, vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, thiamin hydrochloride, riboflavin, vitamin B6 hydrochloride, vitamin B12, niacinamide, folic acid, calcium pantothenate, biotin, ascorbic acid, choline chloride, inositol, calcium carbonate, calcium phosphate, magnesium phosphate, ferrous sulfate, zinc sulfate, manganese sulfate, cupric sulfate, sodium selenite, sodium citrate, potassium chloride, potassium iodide, taurine, L-carnitine.

      Ingredients: (2 & 6 fl oz Nursette® bottles, 8 fl oz bottle): Water, corn syrup solids, partially hydrolyzed nonfat milk and whey protein concentrate solids (soy), vegetable oil (palm olein, soy, coconut and high oleic sunflower oils), rice starch and less than 1%: Mortierella alpina oil*, Crypthecodinium cohnii oil, vitamin B12, vitamin D3, ascorbic acid, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, riboflavin, thiamin hydrochloride, vitamin B6 hydrochloride, choline chloride, inositol, folic acid, vitamin K1, biotin, diacetyl tartaric esters of mono- and diglycerides (DATEM), calcium carbonate, calcium phosphate, magnesium chloride, ferrous sulfate, zinc sulfate, sodium citrate, cupric sulfate, manganese sulfate, potassium iodide, sodium selenite, taurine, L-carnitine.

      * A source of arachidonic acid (ARA).

      † A source of docosahexaenoic acid (DHA).

  • Potential Allergens
    • Enfamil® Gentlease® contains milk and soy.

  • Amino Acid Composition
    • ESSENTIAL AMINO ACIDS
      mg/100 Calmg/100 g Pwd
      Histidine58290
      Isoleucine133680
      Leucine2501250
      Lysine2101050
      Methionine53270
      Cysteine42210
      Phenylalanine97490
      Tyrosine92470
      Threonine140710
      Tryptophan40200
      Valine140710
      NONESSENTIAL AMINO ACIDS
      mg/100 Calmg/100 g Pwd
      Arginine69350
      Alanine101510
      Aspartic Acid2301150
      Glutamic Acid4602300
      Glycine46230
      Proline184940
      Serine131670
      Tyrosine92470
      Threonine140710
      Tryptophan40200
      Valine140710
  • Preparation of Feedings
    • Powder

      The baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Powdered infant formulas are not sterile and should not be fed to premature infants or infants who might have immune problems unless directed and supervised by a doctor. Discuss with parents which formula is appropriate for the baby.

      Discuss with parents whether they need to use cooled, boiled water for mixing and whether they need to boil clean utensils, bottles and nipples in water before use.

      WARNING: Do not use a microwave oven to warm formula. Serious burns may result.

      Refer to the product label for the most accurate information.

      Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use formula within 1 hour or discard.

      1. Wash hands thoroughly with soap and water before preparing formula.
      2. Pour desired amount of water into bottle. Add powder.
      3. Cap bottle and SHAKE WELL.

      Use the charts below for correct amounts of water and powder. Use scoop in tub or can to measure powder. Store DRY scoop in lid holder in tub or in can.

      Enfamil Gentlease

      To Make*

      Water

      Powder

      Weight

      2 fl oz bottle

      2 fl oz

      1 unpacked level scoop

      8.7 g

      4 fl oz bottle

      4 fl oz

      2 unpacked level scoops

      17.4 g

      8 fl oz bottle

      8 fl oz

      4 unpacked level scoops

      34.8 g

      * Each scoop adds about 0.2 fl oz to the amount of prepared formula.

    • Nursette<sup>®</sup> Bottles

      The baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Discuss with parents which formula is appropriate for the baby.

      2 & 6 fl oz Nursette® Bottles

      1. Inspect each bottle for signs of damage.
      2. Wash hands thoroughly with soap and water before preparing bottle for feeding.
      3. SHAKE BOTTLE WELL and remove cap.
      4. Attach nipple unit (not included).

      WARNING: Do not use a microwave oven to warm formula. Serious burns may result.

      Failure to follow these instructions could result in severe harm. Opened bottles can spoil quickly. Either feed immediately or replace cap and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use opened bottle if it is unrefrigerated for more than a total of 2 hours. Do not freeze. After feeding begins, use formula within 1 hour or discard.

    • Ready-to-Use

      The baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Discuss with parents which formula is appropriate for the baby.

      8 fl oz Bottles

      1. Wash hands thoroughly with soap and water before preparing feeding bottles.
      2. SHAKE BOTTLE WELL, remove protective seal around cap, remove cap and foil seal.
      3. Pour into feeding bottle(s).


      WARNING: Do not use a microwave oven to warm formula. Serious burns may
      result.



      Failure to follow these instructions could result in severe harm. Opened bottles and prepared formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 48 hours. Do not use opened bottle and/or prepared formula if they are unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use prepared formula within 1 hour or discard.

  • References
      1. Berseth CL, Johnston WH, Stolz SI, et al. Clinical response to 2 commonly used switch formulas occurs within 1 day. Clin Pediatr (Phila). 2009;48:58-65.
      2. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464.
      3. Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412.
      4. Birch EE, Khoury JC, Berseth CL, et al. The impact of early nutrition on incidence of allergic manifestations and common respiratory illnesses in children. J Pediatr. 2010;156:902-906.
      5. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14.
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