Digestive Health and Soft Stools

What are Prebiotics and How they Work in Infants

Explanation of prebiotics vs. probiotics and the stool-softening effect of the prebiotics blend found in Enfamil Reguline.


  • While stooling discomfort can be an issue for infants, parents are also concerned.

    Managing infant stooling discomfort: soften stools and keep them soft

    While stooling discomfort can be an issue for infants, parents are also concerned. It’s not surprising that about 3% of general pediatric visits and 25% of pediatric gastroenterology consultations are related to a perceived stooling issue.1

  • Stooling solutions should be fast and made to last

    There are a number of solutions for stooling discomfort that are effective for addressing the issue quickly. What also needs to be considered is how long their effects will last and what effort is needed on the parents' part to ensure the issue does not recur.

    Conventional practices for managing stooling issues in infants


    Fruit Juice
    Dosing is not standardized; must be added to diet on a regular basis; contains sugar2

    Glycerin Suppository
    Only for occasional use3

    Corn Syrup
    Dosing is not standardized; must be added to diet on a regular basis; contains sugar2

    Bicycling baby’s legs
    Must be added to the daily routine; easy to forget4

    Look to prebiotics to work like fiber to help promote stooling comfort throughout the first year.

    Prebiotics work much like fiber, something parents are already familiar with, to promote fast, ongoing stooling comfort.5

  • Reassure parents by recommending Enfamil® Reguline™: offering a blend of 2 prebiotics clinically proven in Enfamil® Infant formula to promote soft stools.

    When stooling irregularity or difficult bowel movements are causes of parental concern, Reguline can help. It is designed to help support digestive health and promote comfortable stools.

    • Blend of 2 prebiotics clinically proven in multiple published, randomized, controlled trials to promote soft stools2-5

    Blend of 2 prebi otics clinically

  • Designed to help support digestive health and promote soft stools.
    • Easy-to-digest partially hydrolyzed protein
    • Complete nutrition you expect from a routine infant formula; DHA and choline to help support brain development
    • Appropriate for infants to continue feeding through 12 months of age to help support digestive health throughout the first year
  • Reguline Formula Details

    Enfamil® Reguline—a formula designed to help support digestive health and promote comfortable stooling


    Help transform parental concern into a positive conversation

    • True constipation as defined by NASPGHAN is rare in infants1*
    • Yet, many parents call with concerns about infant stooling
    • Now these calls offer an opportunity for you to help families support their infants's digestive health and help promote soft stools

    Complete Nutrition you expect from a routine infant formula.

    * NASPGHAN defines constipation as “a delay or difficulty in defecation present for 2 weeks or more”1 NASPGHAN = North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition In Enfamil Infant formula

    How Prebiotics Work

    Blend of 2 prebiotics clinically proven in Enfamil Infant formula to help promote beneficial bacteria in the digestive tract and soften stools.

    Prebiotics are non-digestible carbohydrates similar to human milk oligosaccharides that support digestive health

    Prebiotics are different than probiotics

    Prebiotics are a type of carbohydrate that selectively feeds the beneficial bacteria in the digestive system; probiotics are live beneficial bacteria that are ingested and introduced to the digestive system.

    GOS = galacto-oligosaccharide; PDX = polydextrose

    Proven in 4 Studies

    The blend of 2 prebiotics has been clinically proven in Enfamil® Infant formula to soften stools compared with controls


    Study #1: Scalabrin DMF et al. J Pediatr Gastroenterol Nutr. 2012;54:343-352.

    Double-blind, randomized, controlled, prospective trial2

    • Infants (n=289) aged 21 to 30 days were enrolled to evaluate the effect of prebiotics on stool consistency and fecal microbiota.
    • Study groups: 1) Enfamil® without prebiotics, control, 2) Enfamil with a prebiotics blend of PDX/GOS, 3) breastfed reference group.

    Results:

    Proven in 4 Studies Results

    Study #2: Ashley C et al. Nutr J. 2012;11:38. doi: 10.1186/1475-2891-11-38.

    Double-blind, randomized, controlled, parallel-designed, prospective trial.3

    • Infants (n=419) aged 12 to 16 days were enrolled to evaluate the effect of prebiotics on overall growth and tolerance.
    • Study groups: 1) Enfamil without prebiotics, control, 2) Enfamil with 4 g/L of GOS, or 3) Enfamil with 4 g/L of PDX/GOS.

    Results

    Infants fed a prebiotic blend of PDX/GOS had softer stools vs control at study week 1 (P<0.05).

    Double-blind, randomized, controlled, parallel-designed, prospective trial Results

    Study #3: Ziegler E et al. J Pediatr Gastroenterol Nutr. 2007;44:359-364.

    Double-blind, randomized, controlled, parallel-group, prospective trial4

    • Infants (n=226) aged 14 days were randomized to evaluate the effect of prebiotics on overall growth and tolerance.
    • Study groups: 1) Enfamil® without prebiotics, control, 2) Enfamil with 4 g/L of PDX/GOS

    Results

    Double-blind, randomized, controlled, parallel-group, prospective trial results

    Study #4: Nakamura N et al. Appl Environ Microbiol. 2009;75:1121-1128.

    Double-blind, randomized, controlled, parallel-group, prospective trial5

    • Infants (n=134) aged 13 to 92 days were enrolled to evaluate the effect of prebiotics on tolerance and microbiota populations.
    • Study groups: 1) Enfamil without prebiotics, control, 2) Enfamil with 4 g/L of PDX/GOS, 3) Enfamil with 4 g/L of PDX/GOS/LOS, 4) Enfamil with 8 g/L of PDX/GOS/LOS, or 5) breastfed reference group.
    • In younger infants (aged 21-50 days at the start of the study) who were in the PDX/GOS group,the shifting of the microbial populations in the digestive system was more similar to those of breastfed infants compared with control.

    LOS = lactulose

    Nutritionally Complete

    Designed to provide complete nutrition while helping to support digestive health and soft stools.


    Choose a solution that doesn’t compromise on the nutrition you expect during the first year.

    • Blend of 2 prebiotics clinically proven in Enfamil Infant forumula to promote beneficial bacteria in the digestive tract and to soften stools.2-5
    • Easy-to-digest partially hydrolyzed protein.
    • The same complete nutrition you expect from a term infant formula..
    • Neuro Complete —a blend of nutrients that has DHA and choline, designed to help support brain development

      — DHA has shown to foster early and long-term learning ability from infancy through 5 years of age.7-10‡

  • ‡ Studies compared infants fed Enfamil Infant formula with 0.32% DHA vs discontinued Enfamil without DHA

    References 1. Constipation Guideline Committee of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2006;43:e1-e13. 2. Scalabrin DMF et al. J Pediatr Gastroenterol Nutr. 2012;54:343-352. 3. Ashley C et al. Nutr J. 2012;11:38. doi: 10.1186/1475-2891-11-38. 4. Ziegler E et al. J Pediatr Gastroenterol Nutr. 2007;44:359-364. 5. Nakamura N et al. Appl Environ Microbiol. 2009;75:1121-1128. 6. Hernot DC et al. J Agric Food Chem. 2009;57:1354-1361. 7. Colombo J et al. Pediatr Res. 2011;70:406-410. 8. Drover JR et al. Child Dev. 2009;80:1376-1384. 9. Birch EE et al. Dev Med Child Neurol. 2000;42:174-181. 10. Colombo J et al. Am J Clin Nutr. 2013;98:403-412.