• Phenyl-Free® 1 - Iron-fortified infant formula and medical food powder for infants and toddlers with phenylketonuria (PKU).

Phenyl-Free® 1

Iron-fortified infant formula and medical food powder for infants and toddlers with phenylketonuria (PKU).

Last Updated: Monday, October 5, 2015

FREE Metabolic Starter Case
  • Indication
    • Phenyl-Free 1 is an iron-fortified infant formula and medical food powder that is free of the essential amino acid phenylalanine for infants and toddlers with phenylketonuria (PKU). This product provides all other essential amino acids as well as nonessential amino acids, carbohydrate, fat, essential fatty acids, vitamins and minerals. Use under direct and continuing supervision of a doctor.

  • Product Features
      • DHA and ARA

      • Phenylalanine-free

      • Vitamin and mineral levels meet the U.S. Infant Formula Act requirement per 100 Calories

      • Increased levels of B vitamins, compared to routine infant formulas, for cofactor production

      • Vanilla scent

      • Mixes easily and stays in suspension well

      • Choline, an essential nutrient important for brain development and the normal functioning of cells1-2

  • Nutrients*
    • Per 100 grams Powder
      Calories 500
      Protein equivalent, g 16.2
      Fat, g 26
      Linoleic acid, mg 4000
      DHA, mg 88
      ARA, mg 175
      Carbohydrate, g 51
      Per 100 grams Powder
      Vitamins/Other Nutrients
      Vitamin A, IU 1520
      Vitamin D, IU 380
      Vitamin E, IU 10
      Vitamin K, mcg 40
      Thiamin (Vitamin B1), mcg 1000
      Riboflavin (Vitamin B2), mcg 1000
      Vitamin B6, mcg 1000
      Vitamin B12, mcg 2
      Niacin, mcg 10000
      Folic acid (Folacin), mcg 100
      Pantothenic acid, mcg 3800
      Biotin, mcg 38
      Vitamin C (Ascorbic acid), mg 60
      Choline, mg 124
      Inositol, mg 86
      Taurine, mg 30
      Carnitine, mg 51
      Per 100 grams Powder
      Calcium, mg 660
      Phosphorus, mg 440
      Magnesium, mg 66
      Iron, mg 9.6
      Zinc, mg 8.6
      Manganese, mcg 380
      Copper, mcg 860
      Iodine, mcg 76
      Selenium, mcg 14.1
      Sodium, mg 240
      Potassium, mg 560
      Chloride, mg 430
      Molybdenum, mcg NA
      Chromium, mcg NA

      * Product nutrient values and ingredients are subject to change. Please see product label for current information. † Protein is incomplete since it does not contain the essential amino acid phenylalanine. NA = None Added

  • Nutrient Facts
    • Protein Equivalent (% Calories) 13
      Fat (% Calories) 47
      Carbohydrate (% Calories) 40
      Potential Renal Solute Load (mOsm/100 g powder)3 144
      Osmolality (mOsm/kg water) 350
      Osmolarity (mOsm/L) 320
      Lactose-Free Suitable for someone with lactose intolerance
      Galactose-Free Yes

      † Protein is incomplete since it does not contain the essential amino acid phenylalanine. ‡ Determined at 20 Cal/fl oz dilution.

  • Product Form
    • Phenyl-Free® 1 is available in powder.

      Item #: 892601
      Description: Powder
      Unit Size: 1 lb can
      Cal./Unit: 2280
      Prod. Yield / Unit (fl oz): Varies
      Case: 6 cans per case
      HCPCS Code: B4162
      Reimbursement Code: 00087-510172

      HCPCS Code

  • Composition
    • Ingredients: Corn syrup solids, vegetable oil (palm olein oil, coconut oil, soy oil, high oleic sunflower oil), amino acids (L-glutamine, L-leucine, potassium aspartate, L-lysine hydrochloride, L-tyrosine, L-proline, L-valine, L-isoleucine, L-alanine, L-arginine, L-threonine, L-serine, glycine, L-histidine, L-methionine, L-tryptophan, L-cystine), modified corn starch, sugar, calcium phosphate, and less than 1%: Mortierella alpina oil§, Crypthecodinium cohnii oil||, ethyl vanillin, sodium citrate, potassium citrate, magnesium oxide, ferrous sulfate, potassium chloride, zinc sulfate, cupric sulfate, manganese sulfate, sodium iodide, sodium selenite, choline chloride, inositol, ascorbic acid, niacinamide, calcium pantothenate, vitamin B6 hydrochloride, thiamin hydrochloride, riboflavin, vitamin D3, folic acid, biotin, vitamin K1, vitamin E acetate, vitamin A palmitate, vitamin B12, taurine, L-carnitine.

      § A source of arachidonic acid (ARA). || A source of docosahexaenoic acid (DHA).

  • Preparation of Feeding
    • The child's health depends on carefully following these instructions. Proper hygiene, preparation, dilution, use and storage are important when preparing products. Powdered products are not sterile and should not be fed to premature infants or those persons who might have immune problems unless directed and supervised by a medical professional.

      Discuss with parents whether they need to use cooled, boiled water for mixing and whether they need to boil clean utensils, bottles and nipples in water before use.

      Metabolic clinician should advise parents about the correct amounts of water and powder. Pour the required amount of water into the bottle. Add the correct amount of powder, cap the bottle and shake vigorously.

      If instructed to use the scoop in the can, each scoop (unpacked and leveled) delivers approximately 4.5 g of powder. Store DRY scoop in can.

      Failure to follow these instructions could result in severe harm. Once prepared, product can spoil quickly. Either feed immediately or cover and store in refrigerator at 35°–40°F (2°–4°C) for no longer than 24 hours. Do not use prepared product if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared product. After feeding begins, use within 1 hour or discard.

      Powder Storage (cans)

      Store cans at room temperature. After opening can, keep tightly covered, store in a dry area and use contents within 1 month. Do not freeze powder, and avoid excessive heat.


      To be used only under the supervision of a doctor.

      This product is nutritionally incomplete. Care must be taken to provide enough phenylalanine to support growth, using other foods with phenylalanine as required. The medical professional must carefully and constantly supervise the use of Phenyl- Free® 1 with other foods and liquids and adjust the diet based on frequent blood tests.

      Use by date on bottom of can.

      Nutritional powders are not sterile.

      WARNING: Do not use a microwave oven to warm product. Serious burns may result.

      Not for parenteral (I.V.) use

  • Product Characteristics
    • Fat

      Fat provides 47% of total calories in Phenyl-Free® 1. The fat content is similar to the fat content of human milk and consists of a four-oil vegetable blend of palm olein oil (44%), soy oil (19.5%), coconut oil (19.5%) and high oleic sunflower oil (14.5%), along with ARA and DHA from single cell oils (2.5%).

      ¶ Comparison based on fatty acid profile of typical mature U.S. breast milk.


      Protein equivalents provide 13% of calories in Phenyl-Free 1. The product provides the essential amino acids (except phenylalanine) as well as nonessential amino acids (see Amino Acids table); 53% of the amino acids are essential amino acids. Tyrosine level is 1.6 g ⁄ 100 g powder. Since the product contains no phenylalanine, care must be taken to provide enough phenylalanine from breast milk, infant formula or other foods to support growth.

      Amino Acids

      Essential Amino Acids Per 100 g Powder
      Histidine, mg 410
      Isoleucine, mg 1150
      Leucine, mg 2100
      Lysine, mg 1300
      Methionine, mg 360
      Cystine, mg 240
      Phenylalanine, mg 0
      Tyrosine, mg 1600
      Threonine, mg 750
      Tryptophan, mg 290
      Valine, mg 1250
      Nonessential Amino Acids Per 100 g Powder
      Arginine, mg 970
      Alanine, mg 1070
      Aspartic acid, mg 1280
      Glutamic acid, mg 2600#
      Glycine, mg 580
      Proline, mg 1280
      Serine, mg 630

      # Added as glutamine.


      Carbohydrate provides 40% of total calories in Phenyl-Free 1. The carbohydrate blend is corn syrup solids, modified corn starch and sucrose (table sugar). The sucrose in the product helps neutralize the taste of the amino acids. Phenyl-Free 1 is suitable for someone with lactose intolerance.

      Vitamins and Minerals

      Vitamin and mineral levels in Phenyl-Free 1 meet U.S. Food and Drug Administration requirements per 100 Calories for vitamins and minerals as mandated by the U.S. Infant Formula Act and the associated Code of Federal Regulations 21 C.F.R. part 107.1004. Amounts of B vitamins have been increased above levels in routine infant formulas for cofactor production. An increased level of choline, an essential nutrient important for brain development and the normal functioning of cells1-2, is provided. Calcium, iron, zinc, manganese, and copper levels are higher in order to help meet the needs for these minerals when low-protein solid foods are introduced.

  • References
    • 1. Food and Nutrition Board, Institute of Medicine, Choline. In: Dietary References Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press; 1998:390-422.

      2. Zeisel SH, da Costa KA. Nutr Rev. 2009 Nov 67 (11):615-623.

      3. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11–14.

      4. Nutrient Requirements for Infant Formulas. Code of Federal Regulations 21, C.F.R. 107.100.