• Iron-fortified infant formula and medical food powder for infants, children and adults with glutaric acidemia type 1.

GA

Iron-fortified infant formula and medical food powder for infants, children and adults with glutaric acidemia type 1.

Last Updated: Monday, October 5, 2015

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  • Indication
    • GA is an iron-fortified infant formula and medical food powder that is free of the essential amino acids lysine and tryptophan for infants, children and adults with glutaric acidemia type 1. The product provides the other essential amino acids as well as nonessential amino acids, carbohydrate, fat, essential fatty acids, vitamins and minerals. Use under direct and continuing supervision of a doctor.

  • Product Features
      • DHA and ARA

      • Lysine- and tryptophan-free

      • Vitamin and mineral levels meet the U.S. Infant Formula Act requirements per 100 Calories

      • Increased levels of B vitamins, compared to routine infant formulas, for cofactor production

      • Vanilla scent

      • Mixes easily and stays in suspension well

      • Choline, an essential nutrient important for brain development and the normal functioning of cells1-2

  • Nutrients*
    • Per 100 grams Powder
      Calories 500
      Protein equivalent, g 15.1
      Fat, g 26
      Linoleic acid, mg 4000
      DHA, mg 88
      ARA, mg 175
      Carbohydrate, g 52
      Per 100 grams Powder
      Vitamins/Other Nutrients
      Vitamin A, IU 1520
      Vitamin D, IU 380
      Vitamin E, IU 10
      Vitamin K, mcg 40
      Thiamin (Vitamin B1), mcg 1000
      Riboflavin (Vitamin B2), mcg 1000
      Vitamin B6, mcg 1000
      Vitamin B12, mcg 2
      Niacin, mcg 10000
      Folic acid (Folacin), mcg 100
      Pantothenic acid, mcg 3800
      Biotin, mcg 38
      Vitamin C (Ascorbic acid), mg 60
      Choline, mg 124
      Inositol, mg 86
      Taurine, mg 30
      Carnitine, mg 51
      Per 100 grams Powder
      Minerals
      Calcium, mg 660
      Phosphorus, mg 440
      Magnesium, mg 66
      Iron, mg 9.6
      Zinc, mg 8.6
      Manganese, mcg 380
      Copper, mcg 860
      Iodine, mcg 76
      Selenium, mcg 14.1
      Sodium, mg 240
      Potassium, mg 800
      Chloride, mg 330
      Molybdenum, mcg NA
      Chromium, mcg NA

      * Product nutrient values and ingredients are subject to change. Please see product label for current information. † Protein is incomplete since it does not contain the essential amino acids lysine and tryptophan. NA = None Added

  • Nutrient Facts
    • Protein Equivalent (% Calories) 12
      Fat (% Calories) 47
      Carbohydrate (% Calories) 41
      Potential Renal Solute Load (mOsm/100 g powder)3 140
      Osmolality (mOsm/kg water) 370
      Osmolarity (mOsm/L) 330
      Lactose-Free Suitable for someone with lactose intolerance
      Galactose-Free Yes

      † Protein is incomplete since it does not contain the essential amino acids lysine and tryptophan. ‡ Determined at 20 Cal/fl oz dilution

  • Product Form
    • GA is available in powder.

      Item #: 892901
      Description: Powder
      Unit Size: 1 lb can
      Cal./Unit: 2280
      Prod. Yield / Unit (fl oz): Varies
      Case: 6 cans per case
      HCPCS Code: B4157 or B4162
      Reimbursement Code: 00087-510188

      HCPCS Code

  • Composition
    • Ingredients: Corn syrup solids, vegetable oil (palm olein oil, coconut oil, soy oil, high oleic sunflower oil), amino acids (L‑alanine, L‑leucine, potassium aspartate, L‑proline, L‑valine, L‑isoleucine, L‑arginine, glycine, L‑threonine, L‑phenylalanine, L‑tyrosine, L‑serine, L‑histidine, L‑methionine, L‑cystine), modified corn starch, sugar, calcium phosphate, and less than 1%: Mortierella alpina oil§, Crypthecodinium cohnii oil||, ethyl vanillin, sodium citrate, potassium citrate, potassium chloride, magnesium oxide, ferrous sulfate, zinc sulfate, cupric sulfate, manganese sulfate, sodium iodide, sodium selenite, choline chloride, inositol, ascorbic acid, niacinamide, calcium pantothenate, vitamin B6 hydrochloride, thiamin hydrochloride, riboflavin, vitamin D3, folic acid, biotin, vitamin K1, vitamin E acetate, vitamin A palmitate, vitamin B12, taurine, L‑carnitine.

      § A source of Arachidonic acid (ARA) || A source of docosahexaenoic acid (DHA)

  • Preparation of Feedings
    • The consumer's health depends on carefully following these instructions. Proper hygiene, preparation, dilution, use and storage are important when preparing product. Powdered products are not sterile and should not be fed to premature infants or those persons who might have immune problems unless directed and supervised by a medical professional.

      If being fed to an infant, discuss with parents whether they need to use cooled, boiled water for mixing and whether they need to boil clean utensils, bottles and nipples in water before use.

      Metabolic clinician should advise consumers about the correct amounts of water and powder. Pour the required amount of water into bottle/container. Add the correct amount of powder and shake vigorously.

      If instructed to use the scoop in the can, each scoop (unpacked and leveled) delivers approximately 4.5 g of powder. Store DRY scoop in can.

      Failure to follow these instructions could result in severe harm. Once prepared, product can spoil quickly. Either feed immediately or cover and store in refrigerator at 35°—40°F (2°—4°C) for no longer than 24 hours. Do not use prepared product if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared product. After feeding begins, use within 1 hour or discard.

      Powder Storage (cans)

      Store cans at room temperature. After opening can, keep tightly covered, store in a dry area and use contents within 1 month. Do not freeze powder, and avoid excessive heat.

      CAUTION

      To be used only under the supervision of a doctor.

      This product is nutritionally incomplete. Care must be taken to provide enough lysine and tryptophan to support growth, using other foods with these amino acids as required. Medical professional must carefully and constantly supervise the use of GA with other foods and liquids and adjust the diet based on frequent blood tests.

      Use by date on bottom of can.

      Nutritional powders are not sterile.

      WARNING: Do not use a microwave oven to warm product. Serious burns may result.

      Not for parenteral (I.V.) use.

  • Product Characteristics
    • Fat

      Fat provides 47% of total calories in GA. The fat content is similar to the fat content of human milk and consists of a four-oil vegetable blend of palm olein oil (44%), soy oil (19.5%), coconut oil (19.5%), and high oleic sunflower oil (14.5%) along with ARA and DHA from single cell oils (2.5%). This fat blend provides a fatty acid profile similar to the fatty acid profile of breast milk.

      ¶ Comparison based on fatty acid profile of typical mature U.S. breast milk.

      Protein

      Protein equivalents provide 12% of total calories in GA. The product provides the essential amino acids (except lysine and tryptophan) as well as nonessential amino acids (except glutamic acid - see Amino Acids table); 47% of the amino acids are essential amino acids. Since the product contains no lysine or tryptophan, care must be taken to provide enough lysine and tryptophan from breast milk, infant formula or other foods to support growth.

      Amino Acids

      Essential Amino Acids Per 100 g Powder
      Histidine, mg 420
      Isoleucine, mg 1210
      Leucine, mg 2200
      Lysine, mg 0
      Methionine, mg 360
      Cystine, mg 260
      Phenylalanine, mg 710
      Tyrosine, mg 710
      Threonine, mg 790
      Tryptophan, mg 0
      Valine, mg 1310
      Nonessential Amino Acids
      Arginine, mg 1040
      Alanine, mg 3600
      Aspartic acid, mg 1360
      Glutamic acid, mg 0
      Glycine, mg 1040
      Proline, mg 1360
      Serine, mg 710

      Carbohydrate

      Carbohydrate provides 41% of total calories in GA. The carbohydrate blend is corn syrup solids, modified corn starch and sucrose (table sugar). The sucrose in the product helps neutralize the taste of the amino acids. GA is suitable for someone with lactose intolerance.

      Vitamins and Minerals

      Vitamin and mineral levels in GA meet U.S. Food and Drug Administration requirements per 100 Calories for vitamins and minerals as mandated by the U.S. Infant Formula Act and the associated Code of Federal Regulations 21 C.F.R. part 107.1004. Amounts of B vitamins have been increased above levels in routine infant formulas for cofactor production. An increased level of choline, an essential nutrient important for brain development and the normal functioning of cells1-2, is provided. Calcium, iron, zinc, manganese, and copper levels are higher in order to help meet the needs for these minerals when low-protein solid foods are introduced.

  • References
    • 1. Food and Nutrition Board, Institute of Medicine, Choline. In: Dietary References Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press; 1998:390-422.

      2. Zeisel SH, da Costa KA. Nutr Rev. 2009;67(11):615–623.

      3. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14.

      4. Nutrient Requirements for Infant Formulas. Code of Federal Regulations 21, C.F.R. 107.100.