• Enfamil  Enspire nonGMO Infant Formula

Enfamil® Enspire™

Milk-based powder with iron with two new ingredients: MFGM to foster cognitive development and lactoferrin to support immune health.

Last Updated: Friday, October 27, 2017

  • Description/Indication
    • Enfamil Enspire is a 20 Cal/fl oz milk-based, iron-fortified, routine formula for full-term infants 0–12 months. Enfamil Enspire has two components previously only largely available in breast milk: MFGM to foster cognitive development and lactoferrin to support immune health.

  • Product Features
      • Milk fat globule membrane (MFGM) provides the brain-building advantages of breast milk and is shown to improve cognitive outcomes at 12 months1
      • Lactoferrin supports immune health and brings Enfamil® composition closer to human milk than ever before2
      • DHA at the clinically proven amount of 0.32% of total fatty acids, the same amount as the worldwide breast milk average3,*, and double the amount found in the leading competitor’s product:
        • Clinically proven to support mental, visual and immune system development
        • Clinically shown to improve long-term cognitive outcomes through 5 years of age4,‡
        • Shown to improve respiratory health through the first 3 years of life when infants were fed through 12 months5,‡
      • A Natural Defense® Dual Prebiotic blend of GOS (galactooligosaccharides) and PDX (polydextrose) at 4 g/L is clinically proven to: - Support immune health by promoting the growth of beneficial bacteria (bifidobacteria and lactobacilli)6,7
        • Promote soft stools similar to those reported for breastfed infants8
      • Proprietary Triple Health Guard® blend of brain-nourishing DHA, an exclusive dual prebiotic blend and 30 total nutrients for growth
      • Supports excellent growth
      • Easy-to-digest 60:40 whey-to-casein ratio, patterned after mature breast milk9,§
      • Nucleotides to help support the developing immune system
      • Non-GMO||
      • Kosher/halal

      * Average level of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women3.
      † Enfamil Enspire has not been shown superior to the leading competitor in supporting mental, visual and immune system development.
      ‡ Studies compared infants fed Enfamil with DHA and ARA vs. discontinued Enfamil without DHA and ARA; studied before the addition of prebiotics.
      § Comparison based on whey:casein ratio of typical mature breast milk (15 days to 6 months after birth).
      || Ingredients not genetically engineered. Trace amounts of genetically engineered material may be present in the product, such as from manufacturing environments and process sources. For more information, visit enfamil.com/nonGMO.

  • Nutrients
    • Product nutrient values and ingredients are subject to change. Please see product label for current information.

      (Normal Dilution) Per 100 Calories (5 fl oz) Per 100 mL Per 100 grams
      Powder (500 Cal)
      Protein, g 2.1 1.42 10.5
      Fat, g 5.3 3.6 27
      Linoleic acid, mg 800 540 4000
      Carbohydrate, g 11.2 7.6 56
      Water, g 133 90 2.8
      (Normal Dilution) Per 100 Calories (5 fl oz) Per 100 mL Per 100 grams
      Powder (500 Cal)
      Vitamins/Other Nutrients
      Vitamin A, IU 300 200 1500
      Vitamin D, IU 60 41 300
      Vitamin E, IU 2 1.35 10
      Vitamin K, mcg 9 6.1 45
      Thiamin (Vitamin B1), mcg 80 54 400
      Riboflavin (Vitamin B2), mcg 140 95 700
      Vitamin B6, mcg 60 41 300
      Vitamin B12, mcg 0.3 0.2 1.5
      Niacin, mcg 1000 680 5000
      Folic acid (Folacin), mcg 16 10.8 80
      Pantothenic acid, mcg 500 340 2500
      Biotin, mcg 3 2 15
      Vitamin C (Ascorbic acid), mg 12 8.1 60
      Choline, mg 24 16.2 120
      Inositol, mg 6 4.1 30
      L-carnitine, mg 2 1.35 10
      Taurine, mg 6 4.1 30
      (Normal Dilution) Per 100 Calories (5 fl oz) Per 100 mL Per 100 grams
      Powder (500 Cal)
      Calcium, mg 78 53 390
      Phosphorus, mg 43 29 220
      Magnesium, mg 8 5.4 40
      Iron, mg 1.8 1.22 9
      Zinc, mg 1 0.68 5
      Manganese, mcg 15 10.1 75
      Copper, mcg 75 51 380
      Iodine, mcg 15 10.1 75
      Selenium, mcg 2.8 1.89 14
      Sodium, mg 27 18.3 135
      Potassium, mg 108 73 540
      Chloride, mg 63 43 320
  • Nutrient Facts
    • Nutrient Density 20 Calories/fl oz
      Protein (% Calories) 8.5
      Whey:Casein Ratio 60:40
      Fat (% Calories) 48
      Carbohydrate (% Calories) 43.5
      Potential Renal Solute Load (mOsm/100 Calories)10 19.1
      Potential Renal Solute Load (mOsm/100 mL)10 12.9
      Osmolality (mOsm/kg water) 300
      Osmolarity (mOsm/L) 270
      Lactose-free No
  • Product Forms
    • Enfamil Enspire is available in powder.

    • Item #: 157401
      Description: Enfamil Enspire Powder
      Unit Size: 20.5 oz tub
      Cal./Unit: 2940
      Prod. Yield / Unit (fl oz): 147
      Case: 4 tubs per case
      Reimbursement Code: 00087-511748

  • Composition
    • Ingredients: Nonfat milk, lactose, vegetable oil (palm olein, coconut, soy and high oleic sunflower oils), whey protein-lipid concentrate (milk), whey protein concentrate and less than 2%: lactoferrin, galactooligosaccharides#, polydextrose#, Mortierella alpina oil**, Crypthecodinium cohnii oil††, potassium citrate, calcium carbonate, calcium phosphate, sodium chloride, potassium chloride, ferrous sulfate, magnesium oxide, zinc sulfate, cupric sulfate, manganese sulfate, potassium iodide, sodium selenite, soy lecithin, choline chloride, ascorbic acid, niacinamide, calcium pantothenate, riboflavin, thiamin hydrochloride, vitamin D3, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, inositol, vitamin E acetate, vitamin A palmitate, nucleotides (cytidine 5’-monophosphate, disodium uridine 5’-monophosphate, adenosine 5’-monophosphate, disodium guanosine 5’-monophosphate), taurine, L-carnitine.

      ¶ A source of MFGM (milk fat globule membrane).
      # A type of prebiotic.
      ** A source of arachidonic acid (ARA).
      †† A source of docosahexaenoic acid (DHA).

  • Potential Allergens
    • Enfamil Enspire contains milk and soy.

  • Preparation of Feedings
    • The baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Powdered infant formulas are not sterile and should not be fed to premature infants or infants who might have immune problems unless directed and supervised by a doctor. Discuss with parents which formula is appropriate for the baby.

      Discuss with parents whether they need to use cooled, boiled water for mixing and whether they need to boil clean utensils, bottles and nipples in water before use.

      WARNING: Do not use a microwave oven to warm formula. Serious burns may result.

      Refer to the product label for the most accurate information.


      Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use formula within 1 hour or discard.

      1. Wash hands thoroughly with soap and water before preparing formula.
      2. Pour desired amount of water into bottle. Add powder.
      3. Cap bottle and SHAKE WELL.

      Use the charts below for correct amounts of water and powder. Use scoop in tub or can to measure powder. Store DRY scoop in lid holder in tub or in can.

      Enfamil® Enspire

      To Make‡‡ Water Powder Weight
      2 fl oz bottle 2 fl oz 1 unpacked level scoop 8.8 g
      4 fl oz bottle 4 fl oz 2 unpacked level scoops 17.6 g
      8 fl oz bottle 8 fl oz 4 unpacked level scoops 35.2 g

      ‡‡ Each scoop adds about 0.2 fl oz to the amount of prepared formula.

      Powder Storage (tubs and pouches)

      Store powder at room temperature; avoid extreme temperatures, avoid extreme temperatures. After opening, keep lid tightly closed, store in a dry area, and use contents within 1 month. Use tub with Enfamil Enspire formula only.

      Keep powder fresh and prevent bacterial growth by assuring tub is clean and completely dry. Completely empty tub and wipe clean with a clean, dry cloth before refilling.

      If you choose to empty the pouch into the tub, you must retain the batch code* and “use by” date sticker from the pouch.

  • References
    • 1. Timby N, Domellöf E, Hernell O, et al. Neurodevelopment, nutrition, and growth until 12 mo of age in infants fed a low-energy, low-protein formula supplemented with bovine milk fat globule membranes: a randomized controlled trial. Am J Clin Nutr 2014;99:860-868.

      2. King JC Jr, Cummings GE, Guo N, et al. A double-blind, placebo-controlled, pilot study of bovine lactoferrin supplementation in bottle-fed infants. J Pediatr Gastroenterol Nutr. 2007;44:245-251.

      3. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464.

      4. Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412.

      5. Birch EE, Khoury JC, Berseth CL, et al. The impact of early nutrition on incidence of allergic manifestations and common respiratory illnesses in children. J Pediatr. 2010;156:902-906.

      6. Scalabrin D, Mitmesser SH, Welling GW, et al. New prebiotic blend of polydextrose and galacto-oligosaccharides has a bifidogenic effect in young infants. J Pediatr Gastroenterol Nutr. 2012;54:343-352.

      7. Salminen S, Endo A, Isolauri E, et al. Early gut colonization with lactobacilli and staphylococcus in infants: the hygiene hypothesis extended. J Pediatr Gastroenterol Nutr. 2016;62:80-86.

      8. Ziegler E, Vanderhoof JA, Petschow B et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr. 2007;44:359-364.

      9. Kunz C, Lönnerdal B. Re-evaluation of the whey protein/casein ratio of human milk. Acta Paediatr. 1992;81:107-112.

      10. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14.

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