• Enspire nonGMO Infant Formula


Milk-based powder with iron with two new ingredients: MFGM to foster cognitive development and lactoferrin to support immune health.

Last Updated: Tuesday, April 19, 2016

Enspire by Enfamil® is labeled Non-GMO.*

The ingredients in Enfamil® Enspire™ come from sources that have not been genetically engineered.

* Ingredients not genetically engineered. For more information visit Enfamil.com/nonGMO

Indication: Enspire by Enfamil is a milk-based, iron-fortified formula for full-term infants 0-12 months. Enspire has complete nutrition for any infant for whom routine formula is appropriate. Enspire has two innovative components, MFGM and Lactoferrin, largely found in breast milk.

  • Product Features
    • Key Features of Enfamil Enspire

      Features Benefits
      Bovine lactoferrin Supports gut health and brings Enfamil composition closer to human milk than ever before1
      Milk Fat Globule Membrane (MFGM) Supports brain development, and brings Enfamil composition closer to human milk than ever before2
      Non-GMO formulation Some consumers prefer a non-GMO infant formula. By providing a non-GMO formulation, consumer appeal is maximized. There is no evidence that formulas without genetically modified ingredients are safer or more nutritive
      Has LCPUFA (DHA and ARA at 0.32% and 0.64% of total fatty acids, respectively) Clinically shown in Enfamil Infant to promote learning ability from infancy through age 53.
      Dual Prebiotics Blend (PDX and GOS) Supports an infant’s natural defenses by fostering the growth of beneficial bacteria throughout the large intestine; provides stool consistency similar to that of breast fed infants5-7

  • Nutrients
    • (Normal Dilution) Per 100 Calories (5 fl oz) Per 100 grams Powder (500 Cal)
      Protein, g 2.1 10.5
      Fat, g 5.3 27
      Linoleic acid, mg 800 4000
      Carbohydrate, g 11.2 56
      Water, g 133 2.8
      (Normal Dilution) Per 100 Calories (5 fl oz) Per 100 grams Powder (500 Cal)
      Vitamins/Other Nutrients
      Vitamin A, IU 300 1500
      Vitamin D, IU 60 300
      Vitamin E, IU 2 10
      Vitamin K, mcg 9 45
      Thiamin (Vitamin B1), mcg 80 400
      Riboflavin (Vitamin B2), mcg 140 700
      Vitamin B6, mcg 60 300
      Vitamin B12, mcg 0.3 1.5
      Niacin, mcg 1000 5000
      Folic acid (Folacin), mcg 16 80
      Pantothenic acid, mcg 500 2500
      Biotin, mcg 3 15
      Vitamin C (Ascorbic acid), mg 12 60
      Choline, mg 24 120
      Inositol, mg 6 30
      (Normal Dilution) Per 100 Calories (5 fl oz) Per 100 grams Powder (500 Cal)
      Calcium, mg 78 390
      Phosphorus, mg 43 220
      Magnesium, mg 8 40
      Iron, mg 1.8 9
      Zinc, mg 1 5
      Manganese, mcg 15 75
      Copper, mcg 75 380
      Iodine, mcg 15 75
      Selenium, mcg 2.8 14
      Sodium, mg 27 135
      Potassium, mg 108 540
      Chloride, mg 63 320

      † Product nutrient values and ingredients are subject to change. Please see product label for current information.

  • Nutrient Facts
    • Nutrient Density 20 Calories/fl oz
      Protein (% Calories) 8.5
      Fat (% Calories) 48
      Carbohydrate (% Calories) 43.5
      Potential Renal Solute Load (mOsm/100 Calories)10 19.1
      Potential Renal Solute Load (mOsm/100 mL)10 12.9
      Osmolality (mOsm/kg water) 300
      Osmolarity (mOsm/L) 270
      Lactose-Free No
      Galactose-Free No
  • Product Forms
    • Enfamil Enspire is available in powder.

    • Item #: 157401
      Description: Enfamil Enspire Powder
      Unit Size: 20.5 oz tub
      Cal./Unit: 2940
      Prod. Yield / Unit (fl oz): 147
      Case: 4 tubs per case
      Reimbursement Code: 00087-511748

  • Composition
    • Ingredients: Nonfat milk, lactose, vegetable oil (palm olein, coconut, soy, and high oleic sunflower oils), whey protein-lipid concentrate (milk), whey protein concentrate, and less than 2%: lactoferrin, galactooligosaccharides§, polydextrose§, Mortierella alpina oil||, Crypthecodinium cohnil oil, potassium citrate, calcium carbonate, calcium phosphate, sodium chloride, potassium chloride, ferrous sulfate, magnesium oxide, zinc sulfate, cupric sulfate, manganese sulfate, potassium iodide, sodium selenite, soy lecithin, choline chloride, ascorbic acid, niacinamide, calcium pantothenate, riboflavin, thiamin hydrochloride, vitamin D3, Vitamin B6, hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, inositol, vitamin E acetate, vitamin A palmitate, nucleotides (cytidine 5'-monophosphate, disodium uridine 5' - monophosphate, adenosine 5' - monophosphate, disodium guanosine 5' - monophosphate), taurine, L-carnitine.

      ‡ A source of MFGM (Milk Fat Globule Membrane) § A type of prebiotic || A source of arachidonic acid (ARA) ¶ A source of docosahexaenoic acid (DHA)

  • Potential Allergens
    • Enfamil® Enspire contains milk and soy.

  • Preparation of Feedings
    • Powder Formula

      The baby’s health depends on carefully following these instructions. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Powdered infant formulas are not sterile and should not be fed to premature infants or infants who might have immune problems, unless directed and supervised by a doctor.

      Discuss with parents whether they need to use cooled, boiled water for mixing and whether they need to boil clean utensils, bottles and nipples in water before use.


      1. Wash hands thoroughly with soap and water before preparing formula.
      2. Pour the desired amount of water into the bottle. Add powder.
      3. Cap bottle and SHAKE WELL.

      Use the following chart for correct amounts of water and powder. Use scoop in can to measure powder. Store DRY scoop in its original can.

      To Make# Water Powder Weight
      2 fl oz 2 fl oz 1 unpacked level scoop 8.8 g
      4 fl oz 4 fl oz 2 unpacked level scoops 17.6 g
      6 fl oz 6 fl oz 3 unpacked level scoops 26.4 g
      8 fl oz 8 fl oz 4 unpacked level scoops 35.2 g
      1 quart 28.5 fl oz Not Available 128 g

      # Each scoop adds about 0.2 fl oz to the amount of prepared formula.

      Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use formula within 1 hour or discard.

      Powder Storage (tubs and pouches)

      Store powder at room temperature; avoid extreme temperatures, avoid extreme temperatures. After opening, keep lid tightly closed, store in a dry area, and use contents within 1 month. Use tub with Enfamil Enspire formula only.

      Keep powder fresh and prevent bacterial growth by assuring tub is clean and completely dry. Completely empty tub and wipe clean with a clean, dry cloth before refilling.

      If you choose to empty the pouch into the tub, you must retain the batch code* and “use by” date sticker from the pouch.

      WARNING: Do not use a microwave oven to prepare or warm formula. Serious burns may result.

  • References
    • 1. Timby N, Domellof E, Hernell O et al. Neurodevelopment, nutrition, and growth until 12 mo of age in infants fed a low‐energy, low‐protein formula supplemented with bovine milk fat globule membranes: a randomized controlled trial. Am J Clin Nutr 2014;99:860‐8.

      2. King JC, Cummings GE, Guo N et al. A double‐blind, placebo‐controlled, pilot study of bovine lactoferrin supplementation in bottle‐fed infants. J Pediatr Gastroenterol Nutr 2007;44:245‐51.

      3. Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412.

      4. Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr. 2007;44:359-364.

      5. Nakamura N, Gaskins HR, Collier CT, et al. Molecular ecological analysis of fecal bacterial populations from term infants fed formula supplemented with selected blends of prebiotics. Appl Environ Microbiol. 2009; 75:1121-1128.

      6. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464.

  • Retail Listing
    • Enspire is available now at Amazon.com, Target, and other retailers nationwide.

      Availability varies depending on the size of the store, as all stores do not carry all of these products. Typically, the larger the store, the more likely it is that these products will be available in the store you visit. If you find one of the stores listed above does not have the product you need, please ask the store manager to order the quantity you will need on a monthly basis.

      For your convenience, you can use our Store Locator (Enfamil.com) or visit Amazon.com to purchase this product.