• Enfamil® Reguline® 20.4 oz Tub
  • Enfamil® Reguline® 12.4 oz Can

Enfamil® Reguline®

Designed to help support digestive health and promote soft stools.

Milk-based infant formula that has a prebiotic blend and partially broken down proteins for the first 12 months.

Last Updated: Friday, December 8, 2017

  • Description/Indication
    • Enfamil Reguline is a 20 Cal/fl oz infant formula specifically designed to help support digestive health and promote soft, comfortable stools. Prebiotic blend works in 1 week*. It is designed to be fed when stooling issues, such as occasional difficult bowel movements, are causes of parental concern. Enfamil Reguline has the Enfamil Natural Defense® Dual Prebiotic blend that works like fiber to promote soft stools within 1 week and for as long as the baby consumes the formula. Enfamil Reguline has easy-to-digest proteins that are partially hydrolyzed.

      Enfamil Reguline can be used as an everyday formula throughout an infant’s first year of life.

      Long-Term Usage

      Enfamil Reguline is designed to provide the sole source of nutrition for infants up to age 6 months and provide a major source of nutrition for the remainder of the first year.

      * Proven in Enfami® Infant formula.

  • Product Features
      • Proprietary patented Triple Health Guard® blend of brain-nourishing DHA, Natural Defense Dual Prebiotic blend designed to support immune health and 30 nutrients for growth
      • DHA at the clinically proven amount of 0.32% of total fatty acids and the same amount as the worldwide breast milk average1,†:
        • Clinically shown to improve long-term cognitive outcomes through 5 years of age2,*
      • Natural Defense Dual Prebiotic blend to help support digestive health and clinically proven to promote beneficial bacteria in the digestive tract and soften stools within 1 week of use3,5,6,*
      • Easy-to-digest proteins that are partially hydrolyzed
      • 50% of carbohydrates from lactose
      • Complete nutrition appropriate for infants to continue feeding through 12 months of age to help support digestive health throughout the first year
      • Kosher
      • Proven in Enfamil® Infant formula.

      * Proven in Enfami® Infant formula.
      † Average level of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women1.

  • Nutrients
    • Product nutrient values and ingredients are subject to change. Please see product label for current information.

      (Normal Dilution) Per 100 Calories
      (5 fl oz)
      Per 100 mL Per 100 grams
      (Powder 510 Cal)
      Protein, g 2.3 1.55 11.7
      Fat, g 5.3 3.6 27
      Linoleic acid, mg 780 530 4000
      Carbohydrate, g 11.1 7.5 56
      Water, g 133 90 2.4
      Vitamins/Other Nutrients Per 100 Calories
      (5 fl oz)
      Per 100 mL Per 100 grams
      (Powder 510 Cal)
      Vitamin A, IU 300 200 1520
      Vitamin D, IU 60 41 300
      Vitamin E, IU 2 1.35 10.2
      Vitamin K, mcg 9 6.1 46
      Thiamin (Vitamin B1), mcg 80 54 410
      Riboflavin (Vitamin B2), mcg 140 95 710
      Vitamin B6, mcg 60 41 300
      Vitamin B12, mcg 0.3 0.2 1.52
      Niacin, mcg 1000 680 5100
      Folic acid (Folacin), mcg 16 10.8 81
      Pantothenic acid, mcg 500 340 2500
      Biotin, mcg 3 2 15.2
      Vitamin C (Ascorbic acid), mg 12 8.1 61
      Choline, mg 24 16.2 122
      Inositol, mg 6 4.1 30
      Minerals Per 100 Calories
      (5 fl oz)
      Per 100 mL Per 100 grams
      (Powder 510 Cal)
      Calcium, mg 82 55 420
      Phosphorus, mg 46 31 230
      Magnesium, mg 8 5.4 41
      Iron, mg 1.5 1.01 7.6
      Zinc, mg 1 0.68 5.1
      Manganese, mcg 15 10.1 76
      Copper, mcg 75 51 380
      Iodine, mcg 15 10.1 76
      Selenium, mcg 2.8 1.89 14.2
      Sodium, mg 36 24 183
      Potassium, mg 108 73 550
      Chloride, mg 63 43 320
  • Nutrient Facts
    • Nutrient Density 20 Calories/fl oz
      Protein (% Calories) 9
      Whey:Casein Ratio 60:40
      Fat (% Calories) 48
      Carbohydrate (% Calories) 43
      Potential Renal Solute Load (mOsm/100 Calories)4 21
      Potential Renal Solute Load (mOsm/100 mL)4 14
      Osmolality (mOsm/kg water) 250
      Osmolarity (mOsm/L) 230
      Lactose-free No
  • Product Forms
    • Product Forms

      Enfamil® Reguline® is available in powder.

    • Item #: 167002
      Description: Powder
      Unit Size: 12.4 oz can
      Cal./Unit: 1800
      Prod. Yield / Unit (fl oz): 90
      Case: 6 cans per case
      Reimbursement Code: 00087-511132

    • Item #: 167004
      Description: Powder
      Unit Size: 20.4 oz tub
      Cal./Unit: 2940
      Prod. Yield / Unit (fl oz): 147
      Case: 4 tbus per case
      Reimbursement Code: 00087-511157

  • Composition
    • Ingredients: Partially hydrolyzed nonfat milk and whey protein concentrate solids (soy), vegetable oil (palm olein, coconut, soy and high oleic sunflower oils), corn syrup solids, lactose and less than 2%: polydextrose, galactooligosaccharides, Mortierella alpina oil§, Crypthecodinium cohnii oil||, vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, thiamin hydrochloride, riboflavin, vitamin B6 hydrochloride, vitamin B12, niacinamide, folic acid, calcium pantothenate, biotin, ascorbic acid, choline chloride, inositol, calcium carbonate, calcium phosphate, magnesium phosphate, ferrous sulfate, zinc sulfate, manganese sulfate, cupric sulfate, sodium selenite, sodium citrate, potassium chloride, potassium iodide, taurine, L-carnitine.

      ‡ A type of prebiotic.
      § A source of arachidonic acid (ARA).
      || A source of docosahexaenoic acid (DHA).

  • Potential Allergens
    • Enfamil® Reguline® contains milk and soy.

  • Preparation of Feedings
    • The baby’s health depends on carefully following these instructions. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Powdered infant formulas are not sterile and should not be fed to premature infants or infants who might have immune problems, unless directed and supervised by a doctor.

      Discuss with parents whether they need to use cooled, boiled water for mixing and whether they need to boil clean utensils, bottles and nipples in water before use.

      Powder

      1. Wash hands thoroughly with soap and water before preparing formula.

      2. Pour desired amount of water into bottle. Add powder.

      3. Cap bottle and shake well.

      Use the following chart for correct amounts of water and powder. Use scoop in can to measure powder. Store DRY scoop in its original can.

      To Make# Water Powder Weight
      2 fl oz 2 fl oz 1 unpacked level scoop 8.7 g
      4 fl oz 4 fl oz 2 unpacked level scoops 17.4 g
      6 fl oz 6 fl oz 3 unpacked level scoops 26.1 g
      8 fl oz 8 fl oz 4 unpacked level scoops 34.8 g

      # Each scoop adds about 0.2 fl oz to the amount of prepared formula.

      Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in the refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use within 1 hour or discard.

      Powder Storage (tubs and pouches)

      Store powder at room temperature; avoid extreme temperatures. Refill pouches can be used with reusable Enfamil Reguline tubs, sold separately. After opening, keep pouch or tub lid tightly closed, store in a dry area and use contents within 1 month. Use with Enfamil Reguline formula only.

      Keep powder fresh and prevent bacterial growth by assuring tub is clean and completely dry. Completely empty tub and wipe clean with a clean, dry cloth before refilling.

      If you choose to empty the pouch into the tub, you must retain the batch code and “use by” date sticker from the pouch.

      CAUTION Use product by date on container. Nutritional powders are not sterile.

      Ready To Use

      1. Wash hands thoroughly with soap and water before preparing bottle for feeding.

      2. shake bottle well and remove cap and foil seal.

      3. Pour into feeding bottle(s).

      Failure to follow these instructions could result in severe harm. Opened bottles and prepared bottles can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 48 hours. Do not use opened bottle and/or prepared bottle if they are unrefrigerated for more than a total of 2 hours. Do not freeze prepared bottle. After feeding begins, use within 1 hour or discard.

      Ready To Use Storage

      Store unopened bottles at room temperature. Avoid excessive heat. Do not freeze. Use by date on bottle.

      WARNING: Do not use a microwave oven to prepare or warm formula. Serious burns may result.

  • Clinical Studies & Articles
  • References
    • 1. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464.

      2. Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412.

      3. Ashley C, Johnston WH, Harris CL, et al. Growth and tolerance of infants fed formula supplemented with polydextrose (PDX) and/or galactooligosaccharides (GOS): double-blind, randomized, controlled trial. Nutr J. 2012:11:38.

      4. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14.

      5. Salminen S et al. Early Gut Colonization With Lactobacilli and Staphylococcus in Infants: The Hygiene Hypothesis Extended. J Pediatr Gastroenterol Nutr. 2016;62(1):80-86.

      6. Scalabrin D et al. New Prebiotic Blend of Polydextrose and Galacto-oligosaccharides Has a Bifidogenic Effect in Young Infants. J Pediatr Gastroenterol Nutr. 2012;54(3):343-352

What are Prebiotics and How they Work in Infants

Explanation of prebiotics vs. probiotics and the stool-softening effect of the prebiotics blend found in Enfamil Reguline.