• Enfamil® Reguline® 20.4 oz Tub
  • Enfamil® Reguline® 12.4 oz Can

Enfamil® Reguline®

Designed to help support digestive health and promote soft stools.

Milk-based infant formula that has a prebiotic blend and partially broken down proteins for the first 12 months.

Last Updated: Tuesday, September 13, 2016

Indication: Enfamil Reguline is specifically designed to help support digestive health and promote comfortable stools. It is designed to be fed when perceived stooling issues, such as occasional difficult bowel movements, are causes of parental concern.

Long-Term Usage: Enfamil Reguline is designed to provide the sole source of nutrition for infants up to age 6 months and provide a major source of nutrition for the remainder of the first year.

  • Product Features
      • A Neuro Complete blend of nutrients that are also found in breast milk
      • Has a DHA and ARA blend shown* to foster a child’s learning ability up to age 51
      • Blend of 2 prebiotics proven in Enfamil® Infant formula in published, randomized, controlled trials to soften stools compared with control (Enfamil Infant formula without prebiotics)2-5
      • Has a prebiotic blend proven to soften stools compared to Enfamil Infant formula without prebiotics within 1 week of use3
      • Easy-to-digest proteins that are partially hydrolyzed
      • 50% of carbohydrates from lactose
      • Complete nutrition appropriate for infants to continue feeding through 12 months of age to help support digestive health throughout the first year

      DHA and ARA Fatty Acid Nutrients

      • DHA – 17 mg
      • ARA – 34 mg

      * Shown in Enfamil Infant with DHA and ARA. † Per 100 Calories.

  • Nutrients
    • (Normal Dilution) Per 100 Calories
      (5 fl oz)
      Per 100 grams
      Powder (510 Cal)
      Protein, g 2.3 11.7
      Fat, g 5.3 27
      Linoleic acid, mg 780 4000
      Carbohydrate, g 11.1 56
      Water, g 133 2.4
      Vitamins/Other Nutrients Per 100 Calories
      (5 fl oz)
      Per 100 grams
      Powder (510 Cal)
      Vitamin A, IU 300 1520
      Vitamin D, IU 60 300
      Vitamin E, IU 2 10.2
      Vitamin K, mcg 9 46
      Thiamin (Vitamin B1), mcg 80 410
      Riboflavin (Vitamin B2), mcg 140 710
      Vitamin B6, mcg 60 300
      Vitamin B12, mcg 0.3 1.52
      Niacin, mcg 1000 5100
      Folic acid (Folacin), mcg 16 81
      Pantothenic acid, mcg 500 2500
      Biotin, mcg 3 15.2
      Vitamin C (Ascorbic acid), mg 12 61
      Choline, mg 24 122
      Inositol, mg 6 30
      Minerals Per 100 Calories
      (5 fl oz)
      Per 100 grams
      Powder (510 Cal)
      Calcium, mg 82 420
      Phosphorus, mg 46 230
      Magnesium, mg 8 41
      Iron, mg 1.5 7.6
      Zinc, mg 1 5.1
      Manganese, mcg 15 76
      Copper, mcg 75 380
      Iodine, mcg 15 76
      Selenium, mcg 2.8 14.2
      Sodium, mg 36 183
      Potassium, mg 108 550
      Chloride, mg 63 320

      ‡ Product nutrient values and ingredients are subject to change. Please see product label for current information.

  • Nutrient Facts
    • Nutrient Density 20 Calories/fl oz
      Protein (% calories) 9
      Fat (% calories) 48
      Carbohydrate (% calories) 43
      Potential Renal Solute Load (mOsm/100 Calories)6 21
      Potential Renal Solute Load (mOsm/100 mL)6 14
      Osmolality (mOsm/kg water) 250 (Pwd)
      260 (Liq)
      Osmolarity (mOsm/L) 230
      Lactose-Free No
      Galactose-Free No
  • Product Forms
    • Product Forms

      Enfamil® Reguline™ is available in powder and ready-to-use liquid.

    • Item #: 166901
      Description: RTU
      Unit Size: 8 oz bottle
      Cal./Unit: 160
      Prod. Yield / Unit (fl oz): 8
      Case: 24 bottles per case
      Reimbursement Code: 00087-511108

    • Item #: 167002
      Description: Powder
      Unit Size: 12.4 oz can
      Cal./Unit: 1800
      Prod. Yield / Unit (fl oz): 90
      Case: 6 cans per case
      Reimbursement Code: 00087-511132

    • Item #: 167004
      Description: Powder
      Unit Size: 20.4 oz tub
      Cal./Unit: 2940
      Prod. Yield / Unit (fl oz): 147
      Case: 4 tbus per case
      Reimbursement Code: 00087-511157

  • Composition
    • Ingredients: Powder: Partially hydrolyzed nonfat milk and whey protein concentrate solids (soy), vegetable oil (palm olein, coconut, soy, high oleic sunflower oils), corn syrup solids, lactose and less than 2%: polydextrose§, galactooligosaccharides§, Mortierella alpina oil||, crypthecodinium cohnii oil, vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, thiamin hydrochloride, riboflavin, vitamin B6 hydrochloride, vitamin B12, niacinamide, folic acid, calcium pantothenate, biotin, ascorbic acid, choline chloride, inositol, calcium carbonate, calcium phosphate, magnesium phosphate, ferrous sulfate, zinc sulfate, manganese sulfate, cupric sulfate, sodium selenite, sodium citrate, potassium chloride, potassium iodide, taurine and L-carnitine.

      Ingredients: Ready to Use (8 fl oz bottle): Water, partially hydrolyzed nonfat milk and whey protein concentrate solids (soy), vegetable oil (palm olein, soy, coconut and high oleic sunflower oils), lactose, corn syrup solids and less than 2%: polydextrose§, galactooligosaccharides§, Mortierella alpina oil||, crypthecodinium cohnii oil, rice starch, diacetyl tartaric esters of mono- and diglycerides (datem), calcium carbonate, calcium phosphate, magnesium chloride, ferrous sulfate, zinc sulfate, cupric sulfate, sodium citrate, manganese sulfate, potassium iodide, sodium selenite, ascorbic acid, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, riboflavin, thiamin hydrochloride, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, choline chloride, inositol, vitamin D3, taurine and L-carnitine.

      § A type of prebiotic.
      || A source of arachidonic acid (ARA).
      ¶ A source of docosahexaenoic acid (DHA).

  • Potential Allergens
    • Enfamil® Reguline™ contains milk and soy.

  • Preparation of Feedings
    • The baby’s health depends on carefully following these instructions. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Powdered infant formulas are not sterile and should not be fed to premature infants or infants who might have immune problems, unless directed and supervised by a doctor.

      Discuss with parents whether they need to use cooled, boiled water for mixing and whether they need to boil clean utensils, bottles and nipples in water before use.

      Powder

      1. Wash hands thoroughly with soap and water before preparing formula.

      2. Pour desired amount of water into bottle. Add powder.

      3. Cap bottle and shake well.

      Use the following chart for correct amounts of water and powder. Use scoop in can to measure powder. Store DRY scoop in its original can.

      To Make# Water Powder Weight
      2 fl oz 2 fl oz 1 unpacked level scoop 8.7 g
      4 fl oz 4 fl oz 2 unpacked level scoops 17.4 g
      6 fl oz 6 fl oz 3 unpacked level scoops 26.1 g
      8 fl oz 8 fl oz 4 unpacked level scoops 34.8 g

      # Each scoop adds about 0.2 fl oz to the amount of prepared formula.

      Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in the refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use within 1 hour or discard.

      Powder Storage (tubs and pouches)

      Store powder at room temperature; avoid extreme temperatures. Refill pouches can be used with reusable Enfamil Reguline tubs, sold separately. After opening, keep pouch or tub lid tightly closed, store in a dry area and use contents within 1 month. Use with Enfamil Reguline formula only.

      Keep powder fresh and prevent bacterial growth by assuring tub is clean and completely dry. Completely empty tub and wipe clean with a clean, dry cloth before refilling.

      If you choose to empty the pouch into the tub, you must retain the batch code and “use by” date sticker from the pouch.

      CAUTION Use product by date on container. Nutritional powders are not sterile.

      Ready To Use

      1. Wash hands thoroughly with soap and water before preparing bottle for feeding.

      2. shake bottle well and remove cap and foil seal.

      3. Pour into feeding bottle(s).

      Failure to follow these instructions could result in severe harm. Opened bottles and prepared bottles can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 48 hours. Do not use opened bottle and/or prepared bottle if they are unrefrigerated for more than a total of 2 hours. Do not freeze prepared bottle. After feeding begins, use within 1 hour or discard.

      Ready To Use Storage

      Store unopened bottles at room temperature. Avoid excessive heat. Do not freeze. Use by date on bottle.

      WARNING: Do not use a microwave oven to prepare or warm formula. Serious burns may result.

  • Clinical Studies & Articles
  • References
    • 1.Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412.

      2.Scalabrin DM, Mitmesser SH, Welling GW, et al. New prebiotic blend of polydextrose and galactooligosaccharides has a bifidogenic effect in young infants. J Pediatr Gastroenterol Nutr. 2012;54:343-352.

      3.Ashley C, Johnston WH, Harris CL, et al. Growth and tolerance of infants fed formula supplemented with polydextrose (PDX) and/or galactooligosaccharides (GOS): double-blind, randomized, controlled trial. Nutr J. 2012:11:38.

      4.Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr. 2007;44:359-364.

      5.Nakamura N, Gaskins HR, Collier CT, et al. Molecular ecological analysis of fecal bacterial populations from term infants fed formula supplemented with selected blends of prebiotics. Appl Environ Microbiol. 2009;75:1121-1128.

      6.Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14.

What are Prebiotics and How they Work in Infants

Explanation of prebiotics vs. probiotics and the stool-softening effect of the prebiotics blend found in Enfamil Reguline.